Results 21 to 30 of about 2,924,807 (328)

Cell therapy during machine perfusion [PDF]

Transplant International, 2020
There has been increasing use of organs from extended criteria or donation after circulatory death donors to meet the demands of the transplant waiting list. Over the past decade, there has been considerable progress in technologies to preserve organs prior to transplantation to improve the function of these marginal organs.
Emily R. Thompson, Chloe Connelly, Simi Ali, Neil S. Sheerin, Colin H. Wilson   +4 more
openaire   +2 more sources

Prolonged warm ischemia time increases mitogen-activated protein kinase activity and decreases perfusate cytokine levels in ex vivo rat liver machine perfusion

Frontiers in Transplantation, 2023
IntroductionMachine perfusion is increasingly being utilized in liver transplantation in lieu of traditional cold static organ preservation. Nevertheless, better understanding of the molecular mechanisms underlying the ischemia-reperfusion injury (IRI ...
Joohyun Kim, Seung-Keun Hong, Yongqiang Yang, Alice Lee, Karin M. Hoffmeister, Benjamin N. Gantner, Jong-In Park   +6 more
doaj   +1 more source

The ultrastructural characteristics of porcine hepatocytes donated after cardiac death and preserved with warm machine perfusion preservation. [PDF]

PLoS ONE, 2017
The effects of warm machine perfusion preservation of liver grafts donated after cardiac death on the intracellular three-dimensional ultrastructure of the organelles in hepatocytes remain unclear. Here we analyzed comparatively the ultrastructure of the
Hiroki Bochimoto, Naoto Matsuno, Yo Ishihara, Tatsuya Shonaka, Daisuke Koga, Yoshiki Hira, Yuji Nishikawa, Hiroyuki Furukawa, Tsuyoshi Watanabe   +8 more
doaj   +1 more source

Ex situ Normothermic Split Liver Machine Perfusion: Protocol for Robust Comparative Controls in Liver Function Assessment Suitable for Evaluation of Novel Therapeutic Interventions in the Pre-clinical Setting

Frontiers in Surgery, 2021
Background:Ex situ donor liver machine perfusion is a promising tool to assess organ viability prior to transplantation and platform to investigate novel therapeutic interventions.
Joseph A. Attard, Joseph A. Attard, Joseph A. Attard, Daniel-Clement Osei-Bordom, Daniel-Clement Osei-Bordom, Yuri Boteon, Yuri Boteon, Yuri Boteon, Lorraine Wallace, Lorraine Wallace, Vincenzo Ronca, Vincenzo Ronca, Gary Reynolds, Gary Reynolds, M. T. P. R. Perera, Ye Htun Oo, Ye Htun Oo, Ye Htun Oo, Ye Htun Oo, Hynek Mergental, Hynek Mergental, Hynek Mergental, Darius F. Mirza, Simon C. Afford, Simon C. Afford   +24 more
doaj   +1 more source

Recent Methods of Kidney Storage and Therapeutic Possibilities of Transplant Kidney

Biomedicines, 2022
Kidney transplantation is the standard procedure for the treatment of end-stage renal disease (ESRD). During kidney storage and before implantation, the organ is exposed to damaging factors which affect the decline in condition.
Anna Radajewska, Anna Krzywonos-Zawadzka, Iwona Bil-Lula   +2 more
doaj   +1 more source

Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion

Transplantation Direct, 2022
Background. Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis and allograft rejection.
Nader Abraham, MBBS, Elsa K. Ludwig, DVM, Cecilia R. Schaaf, DVM, PhD, Brittany Veerasammy, DVM, Amy S. Stewart, DVM, PhD, Caroline McKinney, DVM, MPH, John Freund, BS, John Brassil, MS, Kannan P. Samy, MD, Qimeng Gao, MD, MHS, Riley Kahan, MBS, Donna Niedzwiecki, PhD, Diana M. Cardona, MD, Katherine S. Garman, MD, Andrew S. Barbas, MD, Debra L. Sudan, MD, Liara M. Gonzalez, DVM, PhD   +16 more
doaj   +1 more source

Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol.

PLoS ONE, 2023
Vascularized composite allografts (VCAs) refer to en bloc heterogenous tissue that is transplanted to restore form and function after amputation or tissue loss.
Casie A Pendexter, Omar Haque, Mohammadreza Mojoudi, Sarah Maggipinto, Marion Goutard, Simona Baicu, Alexandre G Lellouch, James F Markmann, Gerald Brandacher, Heidi Yeh, Shannon N Tessier, Curtis Cetrulo, Korkut Uygun   +12 more
doaj   +2 more sources

Role of normothermic machine perfusion in liver transplantation: Current trends and outcomes

Surgery in Practice and Science, 2022
Background: Liver transplantation is the only known curative treatment option for end-stage liver diseases and failure; however, there is an imbalance between the number of available liver organs for transplant and the number of patients as recipients ...
Mahmoudreza Moein, Jonathan Capelin, Joseph F. Toth, Dylan Tylor, Zoe M. Weiss, Bhavani G. Murugesan, Reza F. Saidi   +6 more
doaj   +1 more source

Machine perfusion of thoracic organs [PDF]

Journal of Thoracic Disease, 2018
This article summarizes recent knowledge and clinical advances in machine perfusion (MP) of thoracic organs. MP of thoracic organs has gained much attention during the last decade. Clinical studies are investigating the role of MP to preserve, resuscitate, and assess heart and lungs prior to transplantation.
Dirk, Van Raemdonck, Filip, Rega, Steffen, Rex, Arne, Neyrinck   +3 more
openaire   +2 more sources

Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant

JAMA Surgery, 2022
Key Points Question Can oxygenated portable normothermic perfusion of deceased donor livers for transplant improve outcomes compared with the current standard of care using ischemic cold storage?
J. Markmann, M. Abouljoud, R. Ghobrial, Chandra S. Bhati, S. Pelletier, A. Lu, S. Ottmann, T. Klair, C. Eymard, G. Roll, J. Magliocca, T. Pruett, Jorge D. Reyes, S. Black, C. Marsh, Gabriel T. Schnickel, M. Kinkhabwala, S. Florman, S. Merani, A. Demetris, Shoko Kimura, M. Rizzari, A. Saharia, M. Levy, A. Agarwal, F. Cigarroa, J. Eason, Shareef M. Syed, W. Washburn, J. Parekh, Jang I. Moon, Alexander Maskin, H. Yeh, P. Vagefi, M. MacConmara   +34 more
semanticscholar   +1 more source