Results 31 to 40 of about 2,976,436 (174)

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

Liver transplantation, 2022
End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an effective strategy to recover liver grafts having initially been discarded for liver transplantation (LT).
D. Patrono, R. De Carlis, A. Gambella, Francesca Farnesi, A. Podestà, A. Lauterio, F. Tandoi, L. D. De Carlis, R. Romagnoli   +8 more
semanticscholar   +1 more source

Transplantation of discarded livers following viability testing with normothermic machine perfusion

Nature Communications, 2020
There is a limited access to liver transplantation, however, many organs are discarded based on subjective assessment only. Here we report the VITTAL clinical trial (ClinicalTrials.gov number NCT02740608) outcomes, using normothermic machine perfusion ...
H. Mergental, R. Laing, Amanda J. Kirkham, M. Perera, Y. Boteon, J. Attard, D. Barton, S. Curbishley, M. Wilkhu, D. Neil, Stefan G. Hübscher, P. Muiesan, J. Isaac, Keith J. Roberts, M. Abradelo, A. Schlegel, J. Ferguson, H. Cilliers, J. Bion, D. Adams, Chris Morris, P. Friend, C. Yap, S. Afford, Darius F. Mirza   +24 more
semanticscholar   +1 more source

Does machine perfusion improve immediate and short‐term outcomes by enhancing graft function and recipient recovery after liver transplantation? A systematic review of the literature, meta‐analysis and expert panel recommendations

Clinical Transplantation, 2022
Recent evidence supports the use of machine perfusion technologies (MP) for marginal liver grafts. Their effect on enhanced recovery, however, remains uncertain.
A. Ramírez-Del Val, J. Guarrera, R. Porte, M. Selzner, M. Spiro, D. Raptis, P. Friend   +6 more
semanticscholar   +1 more source

Hypothermic Oxygenated Machine Perfusion (HOPE) Prior to Liver Transplantation Mitigates Post-Reperfusion Syndrome and Perioperative Electrolyte Shifts

Journal of Clinical Medicine, 2022
(1) Background: Post-reperfusion syndrome (PRS) and electrolyte shifts (ES) represent considerable challenges during liver transplantation (LT) being associated with significant morbidity.
Fabian Horné, M. Drefs, M. Schirren, D. Koch, Ganildo Cepele, Severin J. Jacobi, E. Payani, N. Börner, J. Werner, M. Guba, D. Koliogiannis   +10 more
semanticscholar   +1 more source

Hyperspectral Imaging as a Tool for Viability Assessment During Normothermic Machine Perfusion of Human Livers: A Proof of Concept Pilot Study

Transplant International, 2022
Normothermic machine perfusion (NMP) allows for ex vivo viability and functional assessment prior to liver transplantation (LT). Hyperspectral imaging represents a suitable, non-invasive method to evaluate tissue morphology and organ perfusion during NMP.
M. Fodor, L. Lanser, J. Hofmann, G. Otarashvili, Marlene Pühringer, B. Cardini, R. Oberhuber, T. Resch, A. Weissenbacher, M. Maglione, C. Margreiter, P. Zelger, J. Pallua, D. Öfner, R. Sucher, T. Hautz, S. Schneeberger   +16 more
semanticscholar   +1 more source

Attention-based convolutional neural network for perfusion T2-weighted MR images preprocessing [PDF]

Proceedings of the XII International Scientific and Practical Conference {\guillemotleft}Current challenges, trends and transformations{\guillemotright}, December 13-16, 2022, Boston, USA, 2023
Accurate skull-stripping is crucial preprocessing in dynamic susceptibility contrast-enhanced perfusion magnetic resonance data analysis. The presence of non-brain tissues impacts the perfusion parameters assessment. In this study, we propose different integration strategies for the spatial and channel squeeze and excitation attention mechanism into ...
arxiv  

The Effect of Hypothermic Machine Perfusion to Ameliorate Ischemia-Reperfusion Injury in Donor Organs

Frontiers in Immunology, 2022
Hypothermic machine perfusion (HMP) has become the new gold standard in clinical donor kidney preservation and a promising novel strategy in higher risk donor livers in several countries.
Laura Knijff, C. van Kooten, R. Ploeg
semanticscholar   +1 more source

Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion

British Journal of Surgery, 2022
A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from Bacteroides fragilis was used successfully to remove type B blood group antigens ...
S. MacMillan, S. Hosgood, M. Nicholson
semanticscholar   +1 more source

The Effects of Free Heme on Functional and Molecular Changes During Ex Vivo Normothermic Machine Perfusion of Human Kidneys

Frontiers in Immunology, 2022
Normothermic machine perfusion (NMP) is a technique of kidney preservation designed to restore cellular metabolism after cold ischemia. Kidneys are perfused with an oxygenated banked red blood cell (RBC) based solution for 1h at 36°C.
S. Hosgood, Tegwen R Elliott, Nina P. Jordan, M. Nicholson   +3 more
semanticscholar   +1 more source

Perfusion Quantification from Endoscopic Videos: Learning to Read Tumor Signatures [PDF]

arXiv, 2020
Intra-operative identification of malignant versus benign or healthy tissue is a major challenge in fluorescence guided cancer surgery. We propose a perfusion quantification method for computer-aided interpretation of subtle differences in dynamic perfusion patterns which can be used to distinguish between normal tissue and benign or malignant tumors ...
arxiv