Results 91 to 100 of about 9,056,628 (331)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Predictive Technology Assessment by Means of a Structure-Based Method of Machine Learning

open access: yesJournal of Machine Engineering, 2020
From a user perspective, the current development of the generic term Industry 4.0 increasingly moves its orientation towards flexible production. Due to increasingly variable products with small quantities and the resulting high degree of adaptability of
Manja Mai-Ly PFAFF   +3 more
doaj   +1 more source

In‐process evaluation of continuous generating gear grinding for maintaining workpiece quality and acoustic behavior of gear wheels

open access: yesEngineering Reports, 2022
Hard finishing of gearings such as continuous generating gear grinding is highly essential for manufacturers due to increasing demands on gearboxes regarding quality and economical aspects, especially in the growing field of electric mobility. Here, high
Jonas Böttger   +4 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Depth indicator and stop aid machining to precise tolerances [PDF]

open access: yes, 1966
Attachment for machine tools provides a visual indication of the depth of cut and a positive stop to prevent overcutting.
Laverty, J. L.
core   +1 more source

PassGAN: A Deep Learning Approach for Password Guessing

open access: yes, 2019
State-of-the-art password guessing tools, such as HashCat and John the Ripper, enable users to check billions of passwords per second against password hashes.
A Ciaramella   +9 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Machine Learning tools for global PDF fits [PDF]

open access: yes, 2018
The use of machine learning algorithms in theoretical and experimental high-energy physics has experienced an impressive progress in recent years, with applications from trigger selection to jet substructure classification and detector simulation among ...
Rojo, Juan
core   +3 more sources

Machine Learning and Artificial Intelligence in CNC Machine Tools, A Review

open access: yesSustainable Manufacturing and Service Economics, 2023
Mohsen Soori, B. Arezoo, Roza Dastres
semanticscholar   +1 more source

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