Results 61 to 70 of about 9,056,628 (331)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Controlled Turning Process for the Production of Friction-Reduced Cylinder Liners with a Defined Free-Form Geometry

open access: yesJournal of Machine Engineering, 2021
Friction in the piston-cylinder system of combustion engines has a great influence on fuel consumption. To reduce the friction of combustion engines, free-form cylinder liners and microstructured cylinder liners have proven to be advantageous.
Berend Denkena   +3 more
doaj   +1 more source

A method of numerically controlled machine part programming [PDF]

open access: yes, 1970
Computer program is designed for automatically programmed tools. Preprocessor computes desired tool path and postprocessor computes actual commands causing machine tool to follow specific path.

core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Influence of the process parameters on the grinding result in continuous generating grinding of cutting tools

open access: yesSN Applied Sciences, 2023
Continuous generating grinding processes have largely replaced discontinuous profile grinding processes in gear manufacturing due to their higher productivity.
Berend Denkena   +3 more
doaj   +1 more source

A Composite Evaluation Model of Sustainable Manufacturing in Machining Process for Typical Machine Tools

open access: yesProcesses, 2019
Machine tool is the basic manufacturing equipment in today’s mechanical manufacturing industry. A considerable amount of energy and carbon emission are consumed in machining processes, the realization of sustainable manufacturing of machine tools have ...
Lishu Lv   +6 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Nanocomposites for Machining Tools [PDF]

open access: yesMaterials, 2017
Machining tools are used in many areas of production. To a considerable extent, the performance characteristics of the tools determine the quality and cost of obtained products. The main materials used for producing machining tools are steel, cemented carbides, ceramics and superhard materials. A promising way to improve the performance characteristics
Daria Sidorenko   +3 more
openaire   +3 more sources

Automation of technological preparation of metal working on heavy machine tools [PDF]

open access: yes, 2018
The programs for selection of the cutting tools construction and cutting regimes are working in unrestricted surroundings elaborate of addition SharpDevelop in language C#.
Klymenko, G. P., Kvashnin, V. V.
core  

Inductive queries for a drug designing robot scientist [PDF]

open access: yes, 2010
It is increasingly clear that machine learning algorithms need to be integrated in an iterative scientific discovery loop, in which data is queried repeatedly by means of inductive queries and where the computer provides guidance to the experiments that ...
A. Lingas   +10 more
core   +1 more source

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