Results 71 to 80 of about 9,056,628 (331)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Secure data storage and service automation for cyber physical production systems through distributed ledger technologies

Journal of Machine Engineering, 2021
In this paper, we use the blockchain technology to design a prototype to secure process data from a 3D-printer. Datastreams are gathered from various sources such as OPC UA servers and autonomous retrofit sensor nodes.
Gordon Lemme, Kilian Armin Nölscher, Erhao Bei, Christian Hermeling, Steffen Ihlenfeldt   +4 more
doaj   +1 more source

Carriage-rail assembly for high-resolution mechanical positioning [PDF]

, 1970
Carriage-rail assembly effects extreme resolution and position accuracy with little friction, and is applicable to such apparatus as optical benches, inspection fixtures, machine tools, and photographic equipment. Directions for assembly construction are
Bosworth, R. H., Roney, B. W.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Investigation of Tool Cooling and Heat Transfer Using Computational Fluid Dynamics Simulations

Journal of Machine Engineering
Thermal errors remain one of the biggest challenges for the precision of cutting machine tools. Aside from optimizations in the machine tool design and behaviour, optimal cutting process parameters and targeted usage of cutting fluid or alternative ...
Christian Naumann, Claus-Dieter Schmidt, Alexander Geist, Steffen Brier, Janine Glanzel, Philipp Klimant, Steffen Ihlenfeldt, Martin Dix   +7 more
doaj   +1 more source

Multi-agent framework based on smart sensors/actuators for machine tools control and monitoring [PDF]

, 2006
Throughout the history, the evolutions of the requirements for manufacturing equipments have depended on the changes in the customers' demands. Among the present trends in the requirements for new manufacturing equipments, there are more flexible and ...
Archimède, Bernard, Desforges, Xavier
core   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Hand-machine tools safety [PDF]

, 2010
Import 29/09/2010Tématem této bakalářské práce je bezpečnost při používání elektrického ručního nářadí. Bakalářská práce obsahuje přehled bezpečnostních požadavků na elektrické ruční nářadí stanovené obecně zákony a blíže elektrotechnickými normami.
Doležálek, Jan
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Machine vision in manufacturing SMEs: a review

Discover Applied Sciences
Automating manufacturing tasks, such as quality control, fault detection, part classification, and inventory management with machine vision systems can significantly improve process efficiency, accuracy, and productivity.
Jonas Werheid, Hannes Behnen, Jan-Henrik Woltersmann, Shengjie He, Tobias Hamann, Anas Abdelrazeq, Robert H. Schmitt   +6 more
doaj   +1 more source