Results 71 to 80 of about 87,256 (241)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

High-speed Fabrication of Micro-channels using Line-based Laser Induced Plasma Micromachining (L-LIPMM) [PDF]

, 2013
Micro-texturing of surfaces has various applications that often involve texturing over large (macro-scale) areas with high precision and resolution. This demands scalability and speed of texturing while retaining feature sizes on the order of a few ?m.
Cao, Jian, Ehmann, Kornel, Malhotra, Rajiv, Saxena, Ishan   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Modelling of cutting process impact on machine tool thermal behaviour based on experimental data [PDF]

, 2017
Achieving high workpiece accuracy is a long-term goal of machine tool designers. There are many causes of workpiece inaccuracy, with thermal errors being the most dominant.
Horejš O., Mareš M.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Roughness evolution of previously milled samples along a polishing test [PDF]

, 2016
In the present work results about roughness evolution along a polishing operation with corundum disks of size Norton 400 are presented. Hardened steel and hardened stainless steel samples were previously subjected to ball-end milling or side milling with
Buj Corral, Irene, Vivancos Calvet, Joan
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Influence of pilot hole on cutting force during threading with wireless holder system

Journal of Advanced Mechanical Design, Systems, and Manufacturing
This paper examines the machining accuracy when simultaneously machining pilot holes and threads, and the machining accuracy when machining threads after pilot hole drilling.
Shota MATSUI, Nobutoshi OZAKI, Toshiki HIROGAKI, Eiichi AOYAMA, Ryo MATSUDA   +4 more
doaj   +1 more source

Process simulation for 5-axis machining using generalized milling tool geometries [PDF]

, 2010
Multi-axis machining (especially 5-axis machining) is widely used in precision machining for automotive, aerospace and die-mold manufacturing. The goal in precision machining is to increase production while meeting high part quality needs which can be ...
Budak, Erhan, Ozkirimli, Omer Mehmet, Özkırımlı, Ömer Mehmet   +2 more
core