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Epidemiology of Machupo Virus Infection
The American Journal of Tropical Medicine and Hygiene, 1965Summary The localities in Bolivia from which cases of hemorrhagic fever have been reported are farming communities with characteristic ecological features. The rodent, Calomys callosus, is an important reservoir host of the Machupo virus. An experimental program of disease control was successfully carried out in San Joaquin, Beni, Bolivia.
K. Johnson
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Chronic Infection of Rodents by Machupo Virus
Science, 1965Machupo virus, the etiologic agent of human hemorrhagic fever in Bolivia, induced chronic asymptomatic infection in laboratory hamsters and colonized individuals of the peridomestic, wild, South American rodent, Calomys callosus . Viruria was detected for more than 500 and 150 days, respectively, in the two species.
K M, Johnson +3 more
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Isolation of Machupo Virus from Wild Rodent Calomys callosus
The American Journal of Tropical Medicine and Hygiene, 1966Summary Nine virus strains were recovered from a small group of tissues from the wild rodent Calomys callosus captured in the area of San Joaquin, Bolivia, in 1963. Each virus was successfully reisolated and shown to be serologically related to Machupo virus, the etiologic agent of Bolivian Hemorrhagic Fever.
K M, Johnson +4 more
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Machupo virus polypeptides: Identification by immunoprecipitation
Archives of Virology, 1985The most abundant protein in purified Machupo virions (Corvallo strain) labelled with 14C-Protein hydrolysate is a 64 K polypeptide which is associated with virion RNAs. Another structural polypeptide, 37 K, solubilized by nonionic detergent seems to be a major surface glycoprotein.
I S, Lukashevich, N N, Lemeshko
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Immune Tolerance in Calomys callosus infected with Machupo Virus
Nature, 1969MACHUPO virus, the aetiological agent of Bolivian haemorrhagic fever, is an ether-sensitive RNA virus immunologically classified as a member of the Tacaribe group of “arboviruses”1–3. Repeated isolation of this virus from the cricetine rodent Calomys callosus4, the demonstration of chronic virus infection with persistent viruria in this animal5, and ...
G, Justines, K M, Johnson
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The American Journal of Tropical Medicine and Hygiene, 1965
Comment and Summary The infant hamster appears to be the most sensitive host system thus far devised for detection of naturally occurring strains of Machupo virus. Infected brains also serve as a convenient source of CF antigens which can be employed for provisional grouping of hamster pathogenic isolates.
P. A. Webb
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Comment and Summary The infant hamster appears to be the most sensitive host system thus far devised for detection of naturally occurring strains of Machupo virus. Infected brains also serve as a convenient source of CF antigens which can be employed for provisional grouping of hamster pathogenic isolates.
P. A. Webb
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Machupo Virus and Bolivian Hemorrhagic Fever: Epidemiology, Pathogenesis, and Control Strategies
Journal of Public Health, Policy, and SocietyMachupo virus, a member of the Mammarenavirus genus within the Arenaviridae family, is the etiological agent of Bolivian Hemorrhagic Fever (BHF). This enveloped virus possesses a bi-segmented, single-stranded ambisense RNA genome. The small (S) segment encodes the glycoprotein precursor (GPC) and nucleoprotein (NP), while the large (L) segment encodes ...
I. H. Iheukwumere +5 more
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Some Characteristics of Machupo Virus, Causative Agent of Bolivian Hemorrhagic Fever
The American Journal of Tropical Medicine and Hygiene, 1967Summary Certain properties of Machupo virus are reported. These include presence of RNA, pH stability in the range of 6.0 to 9.0, rapid thermal inactivation at temperatures of 25°C and higher, and more effective stabilization of infectivity titers after prolonged storage (1 year) at -70°C in media containing protein supplements.
P A, Webb +3 more
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The African Green Monkey as an Alternate Primate Host for Studying Machupo Virus Infection
The American Journal of Tropical Medicine and Hygiene, 1977African green monkeys (Cercopithecus aethiops) are highly susceptible to Bolivian hemorrhagic fever (BHF). Six monkeys were inoculated with 1,000 plague-forming units of Machupo virus, the etiologic agent of BHF. They were observed and monitored for clinical signs, body temperature, viremia, hematologic changes, and virus neutralizing antibody.
F S, Wagner, G A, Eddy, O M, Brand
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