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Chronic Infection of Rodents by Machupo Virus
Science, 1965Machupo virus, the etiologic agent of human hemorrhagic fever in Bolivia, induced chronic asymptomatic infection in laboratory hamsters and colonized individuals of the peridomestic, wild, South American rodent, Calomys callosus . Viruria was detected for more than 500 and 150 days, respectively, in the two species.
P A Webb
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Isolation of Machupo Virus from Wild Rodent Calomys callosus
American Journal of Tropical Medicine and Hygiene, 1966Summary Nine virus strains were recovered from a small group of tissues from the wild rodent Calomys callosus captured in the area of San Joaquin, Bolivia, in 1963. Each virus was successfully reisolated and shown to be serologically related to Machupo virus, the etiologic agent of Bolivian Hemorrhagic Fever.
C E Yunker
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Machupo virus polypeptides: Identification by immunoprecipitation
Archives of Virology, 1985The most abundant protein in purified Machupo virions (Corvallo strain) labelled with 14C-Protein hydrolysate is a 64 K polypeptide which is associated with virion RNAs. Another structural polypeptide, 37 K, solubilized by nonionic detergent seems to be a major surface glycoprotein.
I S, Lukashevich, N N, Lemeshko
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In vitro translation of mRNA species from cells infected with Machupo virus
Archives of Virology, 1987RNA from Machupo virus infected cells was centrifuged in a linear sucrose gradient and RNAs from gradient fractions were tested separately for template activity in a cell-free protein synthesizing system from rabbit reticulocytes. Fraction 15-16 S programmed the synthesis of protein that migrated in SDS-polyacrylamide gel like the nucleocapsid protein ...
I S, Lukashevich +3 more
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A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus
Applied Biochemistry and Biotechnology, 2023Bolivian hemorrhagic fever (BHF) caused by Machupo virus (MACV) is a New World arenavirus having a reported mortality rate of 25-35%. The BHF starts with fever, followed by headache, and nausea which rapidly progresses to severe hemorrhagic phase within 7 days of disease onset.
Zeeshan Ali +9 more
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The African Green Monkey as an Alternate Primate Host for Studying Machupo Virus Infection
American Journal of Tropical Medicine and Hygiene, 1977African green monkeys (Cercopithecus aethiops) are highly susceptible to Bolivian hemorrhagic fever (BHF). Six monkeys were inoculated with 1,000 plague-forming units of Machupo virus, the etiologic agent of BHF. They were observed and monitored for clinical signs, body temperature, viremia, hematologic changes, and virus neutralizing antibody.
Gerald A Eddy
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Some Characteristics of Machupo Virus, Causative Agent of Bolivian Hemorrhagic Fever
American Journal of Tropical Medicine and Hygiene, 1967Summary Certain properties of Machupo virus are reported. These include presence of RNA, pH stability in the range of 6.0 to 9.0, rapid thermal inactivation at temperatures of 25°C and higher, and more effective stabilization of infectivity titers after prolonged storage (1 year) at -70°C in media containing protein supplements.
P A, Webb +3 more
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Molecular Diversity
The Arenaviridae family of viruses includes the Machupo virus (MACV), which is associated with the potentially fatal Bolivian hemorrhagic fever, a disease with a mortality rate of 15%-30% depending on the speed of diagnosis and the availability of health facilities.
Abdulaziz, Alamri +5 more
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The Arenaviridae family of viruses includes the Machupo virus (MACV), which is associated with the potentially fatal Bolivian hemorrhagic fever, a disease with a mortality rate of 15%-30% depending on the speed of diagnosis and the availability of health facilities.
Abdulaziz, Alamri +5 more
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Machupo Virus and Bolivian Hemorrhagic Fever: Epidemiology, Pathogenesis, and Control Strategies
Journal of Public Health, Policy, and SocietyMachupo virus, a member of the Mammarenavirus genus within the Arenaviridae family, is the etiological agent of Bolivian Hemorrhagic Fever (BHF). This enveloped virus possesses a bi-segmented, single-stranded ambisense RNA genome. The small (S) segment encodes the glycoprotein precursor (GPC) and nucleoprotein (NP), while the large (L) segment encodes ...
I. H. Iheukwumere +5 more
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Use of Oral Swabs for Detection of Machupo-Virus Infection in Rodents
The American Journal of Tropical Medicine and Hygiene, 1968G, Justines, K M, Johnson
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