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Proceedings from the Fourth Mesoamerican Symposium "Dr. Roberto Navarro López" on Emerging Zoonotic Disease and Arboviruses: Commenting Insights and Research Findings. [PDF]

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Fernández-Santos NA   +26 more
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Chronic Infection of Rodents by Machupo Virus

Science, 1965
Machupo virus, the etiologic agent of human hemorrhagic fever in Bolivia, induced chronic asymptomatic infection in laboratory hamsters and colonized individuals of the peridomestic, wild, South American rodent, Calomys callosus . Viruria was detected for more than 500 and 150 days, respectively, in the two species.
K M, Johnson   +3 more
openaire   +4 more sources

Immune Tolerance in Calomys callosus infected with Machupo Virus

Nature, 1969
MACHUPO virus, the aetiological agent of Bolivian haemorrhagic fever, is an ether-sensitive RNA virus immunologically classified as a member of the Tacaribe group of “arboviruses”1–3. Repeated isolation of this virus from the cricetine rodent Calomys callosus4, the demonstration of chronic virus infection with persistent viruria in this animal5, and ...
G, Justines, K M, Johnson
openaire   +4 more sources

Epidemiology of Machupo Virus Infection

The American Journal of Tropical Medicine and Hygiene, 1965
Summary The localities in Bolivia from which cases of hemorrhagic fever have been reported are farming communities with characteristic ecological features. The rodent, Calomys callosus, is an important reservoir host of the Machupo virus. An experimental program of disease control was successfully carried out in San Joaquin, Beni, Bolivia.
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Isolation of Machupo Virus from Wild Rodent Calomys callosus

The American Journal of Tropical Medicine and Hygiene, 1966
Summary Nine virus strains were recovered from a small group of tissues from the wild rodent Calomys callosus captured in the area of San Joaquin, Bolivia, in 1963. Each virus was successfully reisolated and shown to be serologically related to Machupo virus, the etiologic agent of Bolivian Hemorrhagic Fever.
K M, Johnson   +4 more
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Machupo virus polypeptides: Identification by immunoprecipitation

Archives of Virology, 1985
The most abundant protein in purified Machupo virions (Corvallo strain) labelled with 14C-Protein hydrolysate is a 64 K polypeptide which is associated with virion RNAs. Another structural polypeptide, 37 K, solubilized by nonionic detergent seems to be a major surface glycoprotein.
I S, Lukashevich, N N, Lemeshko
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A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus

Applied Biochemistry and Biotechnology, 2023
Bolivian hemorrhagic fever (BHF) caused by Machupo virus (MACV) is a New World arenavirus having a reported mortality rate of 25-35%. The BHF starts with fever, followed by headache, and nausea which rapidly progresses to severe hemorrhagic phase within 7 days of disease onset.
Zeeshan Ali   +9 more
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