Immunoinformatics Approach to Design Multi-Epitope-Based Vaccine against Machupo Virus Taking Viral Nucleocapsid as a Potential Candidate [PDF]
Vaccines, 2022 The family members of Arenaviridae include members of the genus Machupo virus, which have bi-segmented negative sense RNA inside the envelope and can be transferred to humans through rodent carriers.
Muhammad Shahzad +2 more
exaly +4 more sources
Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis [PDF]
VirusesMachupo virus (MACV), a member of the Arenaviridae family and causative agent of Bolivian hemorrhagic fever, results in lethality rates of 25–35% in humans.
Stephanie Monticelli +2 more
exaly +4 more sources
A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses [PDF]
VirusesThe Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Junjie Xu +2 more
exaly +4 more sources
Glycoprotein-Specific Polyclonal Antibodies Targeting Machupo Virus Protect Guinea Pigs against Lethal Infection [PDF]
VaccinesConvalescent plasma has been shown to be effective at protecting humans against severe diseases caused by New World (NW) arenaviruses, including Junin virus (JUNV) and Machupo virus (MACV).
Jay Hooper +2 more
exaly +4 more sources
Comparison of Vaccine Platforms for Machupo Virus [PDF]
VaccinesBackground/Objectives: Pathogenic mammarenaviruses cause severe hemorrhagic and neurologic disease in humans. Machupo virus (MACV), a New World (NW) mammarenavirus, causes Bolivian hemorrhagic fever in humans, and there are no approved vaccines. Methods:
Rachel Erickson +6 more
doaj +2 more sources
Isothermal real-time RT-RPA for Machupo virus detection: Field-adaptable sensitivity comparable with laboratory PCR. [PDF]
PLoS ONEIsothermal nucleic acid amplification methods, such as recombinase polymerase amplification (RPA), are becoming increasingly vital as diagnostic platforms for neglected tropical diseases by enabling rapid and accurate detection in under-resourced regions.
Marina A Kapitonova +5 more
doaj +2 more sources
Climate-driven changes in zoonotic risk of arenaviral hemorrhagic fevers in South America [PDF]
npj VirusesClimate change is expected to significantly alter the ecological dynamics of zoonotic diseases, yet its long-term impact on rodent-borne hemorrhagic fevers in South America remains poorly understood.
Pranav S. Kulkarni +6 more
doaj +2 more sources
Machupo Virus Glycoprotein Determinants for Human Transferrin Receptor 1 Binding and Cell Entry [PDF]
PLoS ONE, 2011 Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor ...
Sina Bavari, Sheli Radoshitzky
exaly +2 more sources
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors [PDF]
SLAS DiscoveryEmerging highly pathogenic viruses can pose profound impacts on global health, the economy, and society. To meet that challenge, the National Institute of Allergy and Infectious Diseases (NIAID) established nine Antiviral Drug Discovery (AViDD) centers ...
Yuka Otsuka +9 more
doaj +2 more sources
Immunogenicity of recombinant vesicular stomatitis virus-vectored vaccines expressing the Machupo virus glycoprotein in different genome positions [PDF]
Journal of VirologyRecombinant vesicular stomatitis virus (rVSV) is a powerful vaccine platform that elicits durable cellular and humoral immune responses. rVSV vaccines have successfully been used for various hemorrhagic fever-causing viruses. Here, we create and evaluate
Rachel Erickson, Paul Bates
doaj +2 more sources