Analyzing machupo virus-receptor binding by molecular dynamics simulations [PDF]
PeerJ, 2014 In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein–protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases.
Austin G. Meyer +3 more
doaj +8 more sources
Immunoinformatics Approach to Design Multi-Epitope-Based Vaccine against Machupo Virus Taking Viral Nucleocapsid as a Potential Candidate [PDF]
Vaccines, 2022 The family members of Arenaviridae include members of the genus Machupo virus, which have bi-segmented negative sense RNA inside the envelope and can be transferred to humans through rodent carriers.
Muhammad Naveed +2 more
exaly +4 more sources
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors [PDF]
SLAS DiscoveryEmerging highly pathogenic viruses can pose profound impacts on global health, the economy, and society. To meet that challenge, the National Institute of Allergy and Infectious Diseases (NIAID) established nine Antiviral Drug Discovery (AViDD) centers ...
Yuka Otsuka +9 more
doaj +4 more sources
Glycoprotein-Specific Polyclonal Antibodies Targeting Machupo Virus Protect Guinea Pigs against Lethal Infection [PDF]
VaccinesConvalescent plasma has been shown to be effective at protecting humans against severe diseases caused by New World (NW) arenaviruses, including Junin virus (JUNV) and Machupo virus (MACV).
Joseph W. Golden +2 more
doaj +4 more sources
Machupo Virus Glycoprotein Determinants for Human Transferrin Receptor 1 Binding and Cell Entry [PDF]
PLoS ONE, 2011 Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor ...
Jens H Kuhn, Sina Bavari
exaly +5 more sources
Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis [PDF]
VirusesMachupo virus (MACV), a member of the Arenaviridae family and causative agent of Bolivian hemorrhagic fever, results in lethality rates of 25–35% in humans.
Stephanie R. Monticelli +13 more
doaj +2 more sources
A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses [PDF]
VirusesThe Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Qinglin Kang +13 more
doaj +2 more sources
Isothermal real-time RT-RPA for Machupo virus detection: Field-adaptable sensitivity comparable with laboratory PCR. [PDF]
PLoS ONEIsothermal nucleic acid amplification methods, such as recombinase polymerase amplification (RPA), are becoming increasingly vital as diagnostic platforms for neglected tropical diseases by enabling rapid and accurate detection in under-resourced regions.
Marina A Kapitonova +5 more
doaj +2 more sources
Climate-driven changes in zoonotic risk of arenaviral hemorrhagic fevers in South America [PDF]
npj VirusesClimate change is expected to significantly alter the ecological dynamics of zoonotic diseases, yet its long-term impact on rodent-borne hemorrhagic fevers in South America remains poorly understood.
Pranav S. Kulkarni +6 more
doaj +2 more sources
A STAT1-Knockout Mouse Model for Chapare Virus Infection and Pathogenesis [PDF]
VirusesChapare virus (CHAPV) is an Arenaviridae family member and causative agent of Chapare hemorrhagic fever (CHHF). Endemic to Bolivia, CHAPV was found to be the cause of several outbreaks of CHHF in Bolivia in 2003 and 2019 with high case-fatality rates and
Stephanie R. Monticelli +12 more
doaj +2 more sources