Results 21 to 30 of about 1,606 (115)
Application of spectral library prediction for parallel reaction monitoring of viral peptides
PROTEOMICS, Volume 21, Issue 7-8, April 2021., 2021 Abstract A major part of the analysis of parallel reaction monitoring (PRM) data is the comparison of observed fragment ion intensities to a library spectrum. Classically, these libraries are generated by data‐dependent acquisition (DDA). Here, we test Prosit, a published deep neural network algorithm, for its applicability in predicting spectral ...
Marica Grossegesse +3 more
wiley +1 more source
Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. [PDF]
PLoS Pathogens, 2008 A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and ...
Simon Delgado +11 more
doaj +1 more source
Analyzing machupo virus-receptor binding by molecular dynamics simulations [PDF]
PeerJ, 2014 In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein–protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases.
Austin G. Meyer +3 more
doaj +2 more sources
mBio, 2022 Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng +9 more
doaj +1 more source
Проблемы особо опасных инфекций, 2015 Developed has been the oligonucleotide liquid biochip based on xMAP technology, designed for the laboratory detection of particularly dangerous viral pathogens such as Ebola and Marburg filoviruses, and Machupo , Junin, and Lassa arenaviruses.
V. A. Ternovoy +5 more
doaj +1 more source
Chemical Physics Impact, 2023 The current work is concerned with the theoretical discernment of adsorption processes between the Furo [3,2-c] pyridine-2-carbaldehyde and bimetallic clusters (Cu-Ag, Cu-Au and Cu-Ni).
Sravanthi R +5 more
doaj +1 more source
Coronavirus in human diseases: Mechanisms and advances in clinical treatment
MedComm, Volume 1, Issue 3, Page 270-301, December 2020., 2020 Current mechanisms of anti‐CoV therapeutic strategies. The idea to disturb the normal life cycle of the virus provides significant insights into the clinical treatment strategies. All of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 encode structure proteins (like S protein), nonstructure proteins (eg, PLpro, 3CLpro, RdRp, and helicase), and accessory proteins ...
Panpan Lin +4 more
wiley +1 more source
Computational backbone design enables soluble engineering of transferrin receptor apical domain
Proteins: Structure, Function, and Bioinformatics, Volume 88, Issue 12, Page 1569-1577, December 2020., 2020 Abstract Supply of iron into human cells is achieved by iron carrier protein transferrin and its receptor that upon complex formation get internalized by endocytosis. Similarly, the iron needs to be delivered into the brain, and necessitates the transport across the blood‐brain barrier. While there are still unanswered questions about these mechanisms,
Dick J. Sjöström +3 more
wiley +1 more source
Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes
Cellular Microbiology, Volume 22, Issue 1, January 2020., 2020 Abstract Plasmodium vivax is responsible for most of the malaria infections outside Africa and is currently the predominant malaria parasite in countries under elimination programs. P. vivax preferentially enters young red cells called reticulocytes. Advances in understanding the molecular and cellular mechanisms of entry are hampered by the inability ...
Li‐Jin Chan +3 more
wiley +1 more source
Nature Communications, 2018 The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo ...
Lars E. Clark +12 more
doaj +1 more source