Results 31 to 40 of about 1,606 (115)
Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses
mSphere, 2018 Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological
Fatima Amanat +5 more
doaj +1 more source
PLoS Pathogens, 2021 Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old ...
Nicolás Sarute +6 more
doaj +1 more source
A STAT-1 knockout mouse model for Machupo virus pathogenesis
Virology Journal, 2011 Background Machupo virus (MACV), a member of the Arenaviridae, causes Bolivian hemorrhagic fever, with ~20% lethality in humans. The pathogenesis of MACV infection is poorly understood, and there are no clinically proven treatments for disease.
Shurtleff Amy C +3 more
doaj +1 more source
Frontiers in Microbiology, 2021 Ebola virus infection causes severe hemorrhagic fever, and its mortality rates varied from 25 to 90% in the previous outbreaks. The highly infectious and lethal nature of this virus highlights the need for reliable and sensitive diagnostic methods to ...
Wenwu Yao +5 more
doaj +1 more source
Vaccines for emerging pathogens: prospects for licensure
Clinical &Experimental Immunology, Volume 198, Issue 2, Page 170-183, November 2019., 2019 This review covers the global incidence of disease caused by emerging and re‐emerging pathogens and the availability of vaccines for these. It considers the hurdles to be overcome to achieve comprehensive vaccine coverage and reviews the regulatory mechanisms which may be available to seek approval for human use in emergency situations.
E. D. Williamson, G. E. Westlake
wiley +1 more source
Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses
Vaccines, 2019 The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo +2 more
doaj +1 more source
The HIV glycan shield as a target for broadly neutralizing antibodies
The FEBS Journal, Volume 282, Issue 24, Page 4679-4691, December 2015., 2015 The HIV envelope glycoprotein, Env, is extensively decorated with host‐derived N‐linked glycans. These glycans not only shield conserved protein regions from antibody recognition but, critically, act as epitopes for some of the most broad and potent neutralizing antibodies.
Katie J. Doores
wiley +1 more source
Inhibitors of the Machupo Virus L Endonuclease for Bolivian Hemorrhagic Fever Treatments
MicroorganismsMachupo virus (MACV) is the causal agent of Bolivian Hemorrhagic fever. It is highly pathogenic, has a high mortality rate, and currently lacks specific treatments or vaccines. MACV belongs to the Arenaviridae family, which uses a cap-snatching mechanism
Oluwafoyinsola O. Faniyi +10 more
doaj +1 more source
Virology Journal, 2018 Background Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other arenaviruses in South America Junín virus
Amélie D. Zaza +2 more
doaj +1 more source
Animal Models for the Study of Rodent‐Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Human pathogenic hantaviruses and arenaviruses are maintained in nature by persistent infection of rodent carrier populations. Several members of these virus groups can cause significant disease in humans that is generically termed viral hemorrhagic fever (HF) and is characterized as a febrile illness with an increased propensity to cause acute ...
Joseph W. Golden +4 more
wiley +1 more source