Results 11 to 20 of about 1,606 (115)
A STAT1-Knockout Mouse Model for Chapare Virus Infection and Pathogenesis [PDF]
VirusesChapare virus (CHAPV) is an Arenaviridae family member and causative agent of Chapare hemorrhagic fever (CHHF). Endemic to Bolivia, CHAPV was found to be the cause of several outbreaks of CHHF in Bolivia in 2003 and 2019 with high case-fatality rates and
Stephanie R. Monticelli +12 more
doaj +2 more sources
Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model. [PDF]
PLoS Neglected Tropical DiseasesBackgroundMachupo virus (MACV) is a New World mammarenavirus (hereafter referred to as "arenavirus") and the etiologic agent of Bolivian hemorrhagic fever (BHF).
Emily Mantlo +5 more
doaj +2 more sources
A review of emerging health threats from zoonotic New World mammarenaviruses [PDF]
BMC MicrobiologyDespite repeated spillover transmission and their potential to cause significant morbidity and mortality in human hosts, the New World mammarenaviruses remain largely understudied.
Arianna Lendino +3 more
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Development of reverse genetic tools to study Chapare and Machupo viruses [PDF]
Virology, 2023 Christina Spiropoulou +2 more
exaly +2 more sources
Вестник войск РХБ защиты, 2023 This review is dedicated to the peculiarities of pathogenesis of the experimental Bolivian hemorrhagic fever (BHF) - the disease, caused by Machupo virus (Arenaviridae family).
T. E. Sizikova +4 more
doaj +1 more source
Ribonucleoprotein transport in Negative Strand RNA viruses
Biology of the Cell, Volume 115, Issue 1, January 2023., 2023 The genome replication of Negative‐sense, single‐stranded RNA viruses most‐often segregate in membrane‐less environments called inclusion bodies (IBs). These “organelles” usually locate far from the cell surface from where new virions are released. Here, for each viral family, we discuss how the genome progeny is transported from the IBs to reach the ...
Cédric Diot +2 more
wiley +1 more source
Reviews of Geophysics, Volume 60, Issue 4, December 2022., 2022 Abstract Tropical forests are recognized for their role in providing diverse ecosystem services (ESs), with carbon uptake the best recognized. The capacity of tropical forests to provide ESs is strongly linked to their enormous biodiversity. However, causal relationships between biodiversity and ESs are poorly understood.
L. S. Borma +13 more
wiley +1 more source
Recruitment of dynein and kinesin to viral particles
The FASEB Journal, Volume 36, Issue 5, May 2022., 2022 Abstract Dynein and kinesin are cytoskeletal motor proteins involved in transporting cellular cargos and viruses. Throughout viral infection, they actively participate in the virus life cycle in the cell during entry, genome replication, and departure.
Sayi’Mone Tati, Laleh Alisaraie
wiley +1 more source
Structure of Machupo virus polymerase in complex with matrix protein Z
Nature Communications, 2021 The RNA polymerase L of arenaviruses is of interest for drug design and its activity is inhibited by the matrix protein Z. Here, the authors present the cryo-EM structure of the Machupo virus polymerase L in complex with matrix protein Z and discuss the ...
Jun Ma, Shuangyue Zhang, Xinzheng Zhang
doaj +1 more source
Observation of arenavirus nucleoprotein heptamer assembly
FEBS Open Bio, Volume 11, Issue 4, Page 1076-1083, April 2021., 2021 The nucleoprotein associates with RNA to form a ribonucleoprotein complex. The nucleoprotein trends to self‐assemble into heptameric rings. Theses rings represent stable intermediate states representative of the average full turn of the Arenaviridae ribonucleoprotein filament.
Nicolas Papageorgiou +6 more
wiley +1 more source