Results 41 to 50 of about 2,779 (193)
Co-infecting Reptarenaviruses Can Be Vertically Transmitted in Boa Constrictor [PDF]
, 2017 Boid inclusion body disease (BIBD) is an often fatal disease affecting mainly constrictor snakes. BIBD has been associated with infection, and more recently with coinfection, by various reptarenavirus species (family Arenaviridae). Thus far BIBD has only
Hepojoki, Jussi +6 more
core +2 more sources
Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses
Vaccines, 2019 The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo +2 more
doaj +1 more source
Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding
Journal of Molecular Biology, 2023 Transferrin receptor 1 (TfR) delivers iron across cellular membranes by shuttling the ion carrier protein transferrin. This ability to deliver large protein ligands inside cells is taken advantage of by pathogens to infiltrate human cells. Notably, the receptor's outermost ectodomain, the apical domain, is used as a point of attachment for several ...
Sjöström, Dick J. +7 more
openaire +3 more sources
Vaccines for emerging pathogens: prospects for licensure
Clinical &Experimental Immunology, Volume 198, Issue 2, Page 170-183, November 2019., 2019 This review covers the global incidence of disease caused by emerging and re‐emerging pathogens and the availability of vaccines for these. It considers the hurdles to be overcome to achieve comprehensive vaccine coverage and reviews the regulatory mechanisms which may be available to seek approval for human use in emergency situations.
E. D. Williamson, G. E. Westlake
wiley +1 more source
Virology Journal, 2018 Background Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other arenaviruses in South America Junín virus
Amélie D. Zaza +2 more
doaj +1 more source
Hematology Reports, 2020 World Health Organization (WHO) declared coronavirus disease (COVID-19) a pandemic in March 2020. Currently almost every country in the world has reported cases with moderate to high mortality rates. The European Union (EU), the United States of America (
Seidu A. Richard +2 more
doaj +1 more source
Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage [PDF]
, 2010 Background Several arenaviruses cause severe hemorrhagic fever and aseptic meningitis in humans for which no licensed vaccines are available. A major obstacle for vaccine development is pathogen heterogeneity within the Arenaviridae family.
Maya F Kotturi +12 more
core +2 more sources
The HIV glycan shield as a target for broadly neutralizing antibodies
The FEBS Journal, Volume 282, Issue 24, Page 4679-4691, December 2015., 2015 The HIV envelope glycoprotein, Env, is extensively decorated with host‐derived N‐linked glycans. These glycans not only shield conserved protein regions from antibody recognition but, critically, act as epitopes for some of the most broad and potent neutralizing antibodies.
Katie J. Doores
wiley +1 more source
Animal Models for the Study of Rodent‐Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Human pathogenic hantaviruses and arenaviruses are maintained in nature by persistent infection of rodent carrier populations. Several members of these virus groups can cause significant disease in humans that is generically termed viral hemorrhagic fever (HF) and is characterized as a febrile illness with an increased propensity to cause acute ...
Joseph W. Golden +4 more
wiley +1 more source
Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression [PDF]
, 2017 Junin virus (JUNV), a highly pathogenic New World arenavirus, is the causative agent of Argentine hemorrhagic fever (AHF). The live-attenuated Candid #1 (Can) strain currently serves as a vaccine for at-risk populations. We have previously shown that the
Alexey V. Seregin +7 more
core +1 more source