Results 61 to 70 of about 2,779 (193)
A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.
PLoS Neglected Tropical Diseases, 2020 Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence ...
Steven J Hallam +7 more
doaj +1 more source
The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor. [PDF]
PLoS Neglected Tropical Diseases, 2016 Machupo virus (MACV), a New World arenavirus, is the etiological agent of Bolivian hemorrhagic fever (BHF). Junin virus (JUNV), a close relative, causes Argentine hemorrhagic fever (AHF).
Takaaki Koma +7 more
doaj +1 more source
Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses
Journal of Infection and Public Health, 2023 Background: Multiplex real-time PCR is a quick and cost effective method for detection of various gene simultaneously. HFSV (Hemorrhagic Fever Syndrome Virus) is a newly emerging infectious disease because of globalization and climate change. We tried to
Yoonhyuk Choi, Younghee Kim
doaj +1 more source
Rapid Sequence Identification of Potential Pathogens Using Techniques from Sparse Linear Algebra
, 2015 The decreasing costs and increasing speed and accuracy of DNA sample collection, preparation, and sequencing has rapidly produced an enormous volume of genetic data. However, fast and accurate analysis of the samples remains a bottleneck. Here we present
Chiu, Nelson +4 more
core +1 more source
Pathogens, 2015 Arenaviruses include multiple human pathogens ranging from the low-risk lymphocytic choriomeningitis virus (LCMV) to highly virulent hemorrhagic fever (HF) causing viruses such as Lassa (LASV), Junin (JUNV), Machupo (MACV), Lujo (LUJV), Sabia (SABV ...
Junjie Shao, Yuying Liang, Hinh Ly
doaj +1 more source
Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production
Frontiers in Microbiology, 2020 Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo +6 more
doaj +1 more source
DNAZYMES AS A METHOD FOR NIPAH HENIPAVIRUS DETECTION
International Journal of Infectious Diseases, 2023 Intro: Deoxyribozymes (Dz) are short synthetic DNA oligonucleotides that catalyze the cleavage of a phosphodiester bond between nucleotides in the presence of divalent metal ions.
A. Kirichenko +4 more
doaj +1 more source
Modelling the severe acute respiratory syndrome epidemic [3] [PDF]
, 2003 published_or_final_versio
Chau, PH, Yip, PSF
core
RNA ligands activate the Machupo virus polymerase and guide promoter usage
Proceedings of the National Academy of Sciences, 2019 Significance Atomic structures of the polymerase–endonuclease complex of the orthomyxovirus influenza and the orthobunyavirus La Crosse—two distinct segmented negative-sense (SNS) RNA viruses—demonstrate that binding of the genomic 5′ RNA rearranges the catalytic residues of the RNA-dependent RNA-polymerase (RdRP). Working with the arenavirus,
Pyle, Jesse D., Whelan, Sean P. J.
openaire +2 more sources