Results 81 to 90 of about 2,779 (193)
Scientific Reports, 2017 Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain Carvallo termed Car91 that was attenuated in guinea pigs.
Joseph W. Golden +6 more
doaj +1 more source
The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers
Проблемы особо опасных инфекций, 2018 Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses.
T. E. Sizikova +3 more
doaj +1 more source
Pathogenesis of Machupo virus infection in primates.
Bulletin of the World Health Organization, 1976 Experimental Machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. Cumulative mortality during the two phases was 80% and 95% respectively. Attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the ...
G A, Eddy +3 more
openaire +1 more source
Проблемы особо опасных инфекций, 2014 The members of the Filoviridae (Marburg and Ebola viruses) and Arenaviridae (Lassa, Lujo, Machupo, Junin, Guanarito, Sabia viruses) families are the etiological agents of particularly dangerous viral hemorrhagic fevers.
A. A. Petrov +6 more
doaj +1 more source
Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity. [PDF]
, 2013 Several arenaviruses can cause severe hemorrhagic fever (HF) in humans, representing a public health threat in endemic areas of Africa and South America.
Damonte, Elsa Beatriz +4 more
core +2 more sources
PLoS Pathogens, 2009 Arenaviruses are the causative pathogens of severe hemorrhagic fever and aseptic meningitis in humans, for which no licensed vaccines are currently available. Pathogen heterogeneity within the Arenaviridae family poses a significant challenge for vaccine
Maya F Kotturi +17 more
doaj +1 more source
A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry
Molecular Therapy: Nucleic Acids, 2016 Pathogenic New World hemorrhagic fever mammarenaviruses (NWM) utilize Glycoprotein 1 (GP1) to target the apical domain of the human transferrin receptor (hTfR) for facilitating cell entry. However, the conservation between their GP1s is low.
Keith E Maier +8 more
doaj +1 more source
Diabetes as a tracer condition in international benchmarking of health systems.
, 2006 OBJECTIVE: To assess the performance of health systems using diabetes as a tracer condition. RESEARCH DESIGN AND METHODS: We generated a measure of "case-fatality" among young people with diabetes using the mortality-to-incidence ratio (M/I ratio) for 29
Bain, Chris, McKee, Martin, Nolte, Ellen
core +1 more source
The introduction of bioterrorism in Malaysia: A legal approach [PDF]
, 2012 The deliberate use of biological agents and the emergence of infectious diseases which can produce harm to human health and give effects to the public health and security are well recognised.A few years back, an attack of biological agents would be the ...
Abdul Rahim, Rohani, Abdullah, Nor Anita
core +1 more source
Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. [PDF]
, 2014 Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses.
Davis, Benjamin +11 more
core +2 more sources