Results 71 to 80 of about 13,257 (251)

Macrocyclization by asparaginyl endopeptidases [PDF]

New Phytologist, 2017
Contents Summary 923 I. Introduction 923 II. Plant AEPs with macrocyclizing ability 924 III. Mechanism of macrocyclization by AEPs 925 IV. Conclusions 927 Acknowledgements 927 References 927 SummaryPlant asparaginyl endopeptidases (AEPs) are important for the post‐translational processing of seed storage proteins via ...
Amy M, James, Joel, Haywood, Joshua S, Mylne   +2 more
openaire   +2 more sources

Cyclo‐Polyproline: Chameleonic All‐Peptide Macrocycles With Induced‐Fit Host‐Guest Recognition

Angewandte Chemie, EarlyView.
Macrocycles served as the genesis of supramolecular chemistry, advancing synthetic, separation, and materials fields. Despite their utility, they typically lack synthetic control. This work establishes a robust platform for all‐peptide macrocycles capable of host‐guest complexation and chameleonic behavior.
Camilla Di Girolamo, Patricia C. Fleming, Caroline R. Kwawu, Amanda R. Guimarães, Jimmy Muldoon, Julia Bruno‐Colmenarez, Yannick Ortin, Michael R. Probert, Felipe Fantuzzi, Aniello Palma   +9 more
wiley   +2 more sources

Physiological and Biomechanical Evaluation of a Training Macrocycle in Children Swimmers

Sports, 2019
Physiological responses related to 400-m front crawl performance were examined in a 11-week training macrocycle in children 11.6 ± 1.2 years old. Fourteen girls and twenty-nine boys completed a maximum intensity 400-m test, at the beginning (&Tau ...
Sara Ferreira, Diogo Carvalho, Ana Sofia Monteiro, J. Arturo Abraldes, J. Paulo Vilas-Boas, Argyris Toubekis, Ricardo Fernandes   +6 more
doaj   +1 more source

Cyclo[Tri(thiomethyl-1,2-phenylmethylene)]

Molbank
During the purification of a reported compound named 1,3-dihydrobenzo[c]thiophene, we isolated an unexpected molecule in one of the chromatography fractions by serendipity.
Pablo Simón Marqués, Nicolas Bréfuel, Claire Kammerer   +2 more
doaj   +1 more source

Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors

Molecules, 2020
G protein-coupled receptors (GPCRs), which constitute the most populous family of the human proteome, are the target of 35–45% of approved therapeutic drugs. This review focuses on natural products (excluding peptides) that target GPCRs.
Joan Serrano-Marín, Irene Reyes-Resina, Eva Martínez-Pinilla, Gemma Navarro, Rafael Franco   +4 more
doaj   +1 more source

5,15-Bis(4-pentyloxyphenyl)porphyrin

Acta Crystallographica Section E, 2013
In the title compound, C42H42N4O2, the complete molecule is generated by a crystallographic inversion centre. The porphyrin system exhibits a near planar macrocycle conformation with an average deviation from the least-squares plane of the 24 macrocycle ...
Mathias O. Senge
doaj   +1 more source

macrocycle

, 2014
Citation: 'macrocycle' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.M03662 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Alkali Metal-Ion Binding by a Model Macrocycle Containing a C-I···N Halogen Bonded Network: A DFT Study of C-I···M⁺ and N···M⁺ Binding Interactions, M⁺ = Li⁺, Na⁺, K⁺, and Rb⁺

Inorganics
The complexation of an alkali metal ion by a model macrocycle is examined using the M05-2X/DGDZVP DFT method. The macrocycle is built by connecting three cyclopenta[b]pyrrole motifs with alternating acetylene and ethylene linkages. Replacing one of the C-
Rubén D. Parra
doaj   +1 more source

Rigid Macrocycle Metal Complexes as CXCR4 Chemokine Receptor Antagonists: Influence of Ring Size

Pharmaceutics
Understanding the role of chemokine receptors in health and disease has been of increasing interest in recent years. Chemokine receptor CXCR4 has been extensively studied because of its defined role in immune cell trafficking, HIV infection, inflammatory
Isaline Renard, Thomas D’huys, Benjamin P. Burke, Trisha Ajoleza, Amy N. Cain, Neil L. Funwie, Abid Khan, Danny L. Maples, Randall D. Maples, Dallas L. Matz, Graeme McRobbie, Robert Ullom, Timothy J. Prior, Douglas P. Linder, Tom Van Loy, Timothy J. Hubin, Dominique Schols, Stephen J. Archibald   +17 more
doaj   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source