Results 121 to 130 of about 9,528 (245)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Redox- and protonation-driven Baird and Clar aromaticity in asymmetric multicyclic octaphyrins. [PDF]

Chem Sci
Ali MA, Kim JH, Kim Y, Nam Y, Oh J, Jang WD, Kim D.   +6 more
europepmc   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

The Missing Element in the World of Macrocycles─<i>p</i>-Pyriporphyrin. [PDF]

Org Lett
Kamyszek J, Myśliborski R, Modelska D, Krzyszowska P, Białek MJ, Gordel-Wójcik M, Chmielewski PJ, Latos-Grażyński L, Hurej K.   +8 more
europepmc   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Synthesis and LCMS Characterization of a 1275-Member Library of 24-Atom Triazine Macrocycles Derived from Quantitative Dimerization Occurring with >99.9% Fidelity. [PDF]

ACS Med Chem Lett
Claton LE, Reddy KHV, Gaines SN, Brown SD, Schluckwerder BC, Elam GT, Gendler DS, Ganz AS, McPhaul LC, Rangel AE, Noland JK, Jackson FA, Bobo GG, Yusufji AJ, Simanek EE, Lee KM.   +15 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

CO₂ Adsorption Capabilities of Functionalized Dyn[4]arenes. [PDF]

ACS Omega
Alektoridis K, Rauls E.
europepmc   +1 more source

Outer‐Sphere Tuning of Synthetic Iron–Sulfur Clusters Within Nanoscale Cage Frameworks

Small, EarlyView.
Noncovalent encapsulation of a synthetic iron–sulfur cluster within hydrophobic, naphthalenediimide (NDI)‐paneled cages is shown to lead to dramatic changes in the electronic structure and covalency of the Fe─S core. ABSTRACT As atomic‐scale archetypes for multi‐electron transfer, iron–sulfur clusters are compelling candidates for the design of redox ...
Rupal Baliyan, Shelby T. Davis, Jan‐Niklas Boyn, Gwendolyn A. Bailey   +3 more
wiley   +1 more source

Massive barcode-free chemical screenings enable the discovery of bioactive macrocycles with passive membrane permeability. [PDF]

Nat Commun
Mata JM, Liu J, McKenna SM, van der Nol E, Havermans M, Delwel R, Filius M, Joo C, Vallaro M, Caron G, Pomplun SJ.   +10 more
europepmc   +1 more source