Results 121 to 130 of about 20,280 (253)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Management of Refractory Thymoma‐Associated Myasthenia Gravis With Sequential FcRn Antagonist and Complement Inhibition Combined With Resection of Pleural Dissemination

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Myasthenia gravis (MG) associated with disseminated thymoma is often refractory to conventional treatments due to continuous autoantibody production. The optimal treatment strategy, particularly the combination of complement component 5 (C5) inhibitor, neonatal Fc receptor (FcRn) antagonist, and surgical resection in thymoma‐associated ...
Hiroyuki Takenaka, Madoka Iida, Yuki Fukami, Masahisa Katsuno   +3 more
wiley   +1 more source

Dynamic Polydisulfide Latex via Emulsion Ring‐Opening Polymerization of Cyclodisulfides

Journal of Polymer Science, EarlyView.
A polydisulfide latex with a high molar mass was achieved by emulsion polymerization process starting from a dithiol. The mechanism reveals an entropy‐driven ring‐opening polymerization involving disulfide macrocycle intermediates. The polydisulfide particles can be degraded by thiol‐disulfide exchange, and the disulfide fragments can be reengaged in a
Sandric Afonso, Pierre‐Louis Quentin, Marc Schmutz, Cécile Joyeux, Cuong Minh Quoc Le, Abraham Chemtob   +5 more
wiley   +1 more source

Pesticide use in integrated pest and pollinator management framework to protect pollinator health

Pest Management Science, Volume 81, Issue 4, Page 1691-1696, April 2025.
Integrated pest management (IPM) emphasizes non‐chemical methods, with pesticides as a last resort, while integrated pest and pollinator management (IPPM) integrates pollinator health into pest control strategies. Abstract Agricultural pesticides have historically been a critical tool in controlling pests and diseases, preventing widespread suffering ...
Ngoc T Phan, David J Biddinger, Edwin G Rajotte, Guy Smagghe, Gadi VP Reddy, Zong‐Xin Ren, Neelendra K Joshi   +6 more
wiley   +1 more source

Structure-Activity Relationship Analysis of Macrocyclic Peptide RAS Inhibitors: Spotlight on the Solvent-Exposed Region. [PDF]

ACS Med Chem Lett
Chiyoda A, Matsuo A, Yamano T, Tanada M.
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Electrochemical investigation of radical‐radical recognition in viologen‐based ditopic structures

Responsive Materials, EarlyView.
The so‐called “blue box” is one of the most studied macrocycles. Yet, functionalized macrocycles of this type are rarely investigated. This work describes the radical‐radical recognition properties of ditopic structures, including functionalized blue‐box macrocycles.
Ahmad Bachir, Fabiana Ciocchetti, Caterina Baccini, Sayed Suliman Shah, Andrea Secchi, Cristian Pezzato, Giulio Ragazzon   +6 more
wiley   +1 more source

A Modular Core–Shell Nanoparticle Platform for Dual‐Modal MRI–Luminescence With High Relaxivity

Small, EarlyView.
A modular core–shell nanoparticle platform is presented that combines high‐relaxivity magnetic resonance imaging (MRI) and long‐lived luminescence within a single, well‐defined architecture. Spatially controlled gadolinium(III) and terbium(III) complexes deliver reproducible dual‐modal agents with benchmark MRI performance.
Catherine J. Ashton, Jonathan Martinelli, Sara Camorali, Thomas R. Berki, Amy J. Managh, Constantina Sofroniou, Lorenzo Tei, Helen Willcock, Stephen J. Butler   +8 more
wiley   +1 more source

Corrigendum: A p-tert-Butyldihomooxacalix[4]arene Based Soft Gel for Sustained Drug Release in Water

Frontiers in Chemistry, 2020
Hao Guo, Hao Guo, Runmiao Zhang, Runmiao Zhang, Ying Han, Jin Wang, Chaoguo Yan   +6 more
doaj   +1 more source