Results 141 to 150 of about 25,151 (288)
Chemistry – A European Journal, EarlyView.Males of the tropical frog Gephyromantis granulatus carry unique ethyl‐branched sesquiterpenoid macrolactones in their scent glands. Their structure elucidation was performed by GC/MS, leading to the proposed structures of the granolides. A flexible enantioselective synthesis confirmed the structures and allowed determination of their absolute ...
Johanna Kuhn +2 more
wiley +1 more source
Isodesmic Supramolecular Assembly of Phenylethynylene Bis‐Urea Macrocycles
Chemistry – A European Journal, EarlyView.A soluble phenylethynylene bis‐urea macrocycle assembles in polar media via an isodesmic hydrogen bonded mechanism. Spectroscopic and morphological studies reveal nanoscale aggregates with short chain length, while guest additives modulate enthalpy and polymerization, demonstrating tunable supramolecular assembly.
Fahidat A. Gbadamosi +5 more
wiley +1 more source
Novel Macrocyclic Compounds Targeting STING for Autoimmune Diseases Treatment. [PDF]
ACS Med Chem LettJiang Y, Liang SH.
europepmc +1 more source
, 2010 51 p.Two new macrocyclic compounds were studied: [Co2L(O2CCHPh2)(py)2]+BF4– 1 , and [Ni4L(O2CCHPh2)2]2+(BF4–)2 2. In addition, previously synthesized [Co2L(OAc)2]·H2O 3 was structurally characterized.
Jary, Hannah K.
core
Chemistry – A European Journal, EarlyView.We report the synthesis and characterization of a sulfated prism[5]arene host (Prism[5]MaxQ). Prism[5]MaxQ displays ultrahigh binding affinity (Ka up to 1012 M−1) toward hydrophobic (di)cations in phosphate‐buffered saline (PBS). The work positions Prism[5]MaxQ as a new member of the family of ultrahigh‐affinity hosts poised for use as a sequestrant in
Emmanuel A. Bazan‐Bergamino +1 more
wiley +1 more source
Thio-modified trianglimines, a novel group of chiral macrocyclic compounds of high structural dynamics. [PDF]
Sci RepPrusinowska N +3 more
europepmc +1 more source
Macrocyclic polyether sulfide syntheses, the preparation of thia-crown-3, 4, 6, and 7 compounds
, 1974 Macrocyclic polyether sulfides have been prepared by reacting an oligoethylene glycol dichloride with a dithiol or sodium sulfide in ethanol. The following new compounds were prepared: 1-thia-(9-crown-3), 1,4-dithia-(9-crown-3), 1,4-dithia-(12-crown-4 ...
Hui, Yau-Kwong Joseph
core
Chemistry – A European Journal, EarlyView.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
Peptide macrocyclic compounds : new perspectives in diagnostic and disease treatment
In recent years macrocyclic peptides have drawn much interest due to their beneficial physiochemical properties and potential medical applications. The goal of this review is to summarize the advantages and drawbacks of macrocyclic peptides and provide ...
Miśkiewicz, Julia +2 more
core +1 more source
Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Chemistry – A European Journal, EarlyView.A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova +11 more
wiley +1 more source