Results 201 to 210 of about 1,721,261 (283)

Efficient synthesis of pillar[5]quinone for rapid identification of aromatic nitro explosives. [PDF]

RSC Adv
Zhang YY, Wang L, Wu J, Fan ST, Che XY, Wang YH, Zhang ZY, Liu YH, Zhou X, Liu Y, Li C.   +10 more
europepmc   +1 more source

Understanding the Dynamics of Mechanically Interlocked Molecular Systems via Metadynamics Simulations

The Chemical Record, EarlyView.
This Personal Account discusses how molecular simulations help uncover motion, shuttling mechanisms, and kinetics in mechanically interlocked molecules such as rotaxanes and catenanes. Mechanically interlocked molecules, such as rotaxanes and catenanes, display complex internal dynamics and reciprocal motions that are central to their use as artificial
Clara Sabrià, Luigi Leanza, Massimo Delle Piane, Max von Delius, Ferran Feixas, Xavi Ribas, Giovanni M. Pavan   +6 more
wiley   +1 more source

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids. [PDF]

J Med Chem
Syphers JL, Wright JA, Kumar A, To N, Elson L, Krämer A, Müller S, Morasch V, Chang A, Young S, Sloan EK, de Nys R, Silva TN, Vrbanac L, Barratt KR, Leeflang J, Hasan ST, Gable RW, Knapp S, Worthley DL, Mukherjee S, Stockton K, Woods SL, Priebbenow DL, Baell JB.   +24 more
europepmc   +1 more source

Establishment of a Human Cell‐Based In Vitro Test System for Investigating and Evaluating Cytotoxic and Immunomodulatory Effects of Indoor Mold

Environmental Toxicology, EarlyView.
ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff, Jessica Reinert, Silke Steinborn, Marion Berger, Judith Neuhoff, Lennart Marske, Kerttu Valtanen, Udo Jäckel, Stefanie Klar   +8 more
wiley   +1 more source

Efficacy of Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) against circulating microfilariae in dogs infected with Dirofilaria immitis. [PDF]

Parasit Vectors
Packianathan R, Ahn KS, Shin S, Cho H, Kim J, Rodriguez J, Geurden T.   +6 more
europepmc   +1 more source

Reactivity of a Pacman Chlorophosphane Toward Ammonia and Azide: Formation and Characterization of a Diamino‐ and a Diazidophosphane

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
Selective ammonolysis and azidation of a Pacman chlorophosphane provide access to diamino‐ and diazidophosphanes. Spectroscopic and computational studies establish their structures, isomerism, and unusual 3 + 2 coordination at phosphorus. The halide substitution reactions of the Pacman chlorophosphane Pac(PCl)2 with NH3 and AgN3 provide straightforward
Pascal Schmidt, Justin Ressel, Leon Ohms, Axel Schulz   +3 more
wiley   +1 more source

Beyond Simple Mimicry: Next-Generation Geometric Architectures and Future Paradigms in Small-Molecule and Macrocyclic Peptidomimetics. [PDF]

Angew Chem Int Ed Engl
Lee J, Son S, Yoo JY, Lee JH, Chun M, Park SB.   +5 more
europepmc   +1 more source

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

Architecting a Bismacrocycle through a Single C-C Bond Connection. [PDF]

JACS Au
Li Y, Li H, Zhou Q, Qu M, Chen P, Xu J, Wang Y, Zhu G, Lu Z.   +8 more
europepmc   +1 more source

Comparative evaluation of reactive dye structures on colour strength enhancement in caustic‐treated regenerated bamboo fabrics

Coloration Technology, EarlyView.
Abstract Regenerated bamboo fibres offer a sustainable alternative to conventional cellulosic materials; however, achieving high and reproducible colour strength with reactive dyes may depend on both fibre accessibility and dye molecular architecture.
Arzu Yavas, Ece Kalayci, Ozan Avinc
wiley   +1 more source