Results 191 to 200 of about 25,151 (288)

A Macrocyclic Bistriazene: Stabilization of the [Ni(Py)2]2+ Complex Cation with 6,15,23,32−Tetraethoxycarbonyl−bis(tolanetriazenediide) Ion as Ligand

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
The arrangement of the complex molecules [Ni((4,4′−EtO(CO)2tolaneN3)2(py)2] and pyridine as crystallization solvate in the solid state based on nonbonded intermolecular interactions such CH⋅⋅⋅py, CH⋅⋅⋅O and CH⋅⋅⋅HC contacts is discussed in this work.
Aline Joana Rolina Wohlmuth Alves dos Santos, Johannes Beck, Manfredo Hörner, Daniel Felipe Pietezak, Robson da Silva Oliboni, Petra Krieger‐Beck, Gertrud Dittmann   +6 more
wiley   +1 more source

Electronic transport in radial π-conjugated macrocyclic molecules: a density functional theory study. [PDF]

RSC Adv
Govindarajan S, Ramya K, Ravva MK, Mukhopadhyay S.   +3 more
europepmc   +1 more source

Unusual backfolded binding poses of BAZ2A bromodomain binders

Acta Crystallographica Section D, EarlyView.
We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove, Giulia Cazzanelli, Vito Giuseppe D'Agostino, Pablo Andres Vargas Rosales, Amedeo Caflisch, Graziano Lolli   +5 more
wiley   +1 more source

Novel amide-based macrocyclic Co(ii) complexes: correlating structural, computational, and biological properties through DFT and docking. [PDF]

RSC Adv
Subhash, Kumar M, Vandana, Devi A, Chaudhary A.   +4 more
europepmc   +1 more source

Anthelmintic resistance in sheep nematodes in Australia: a compilation of recent test results

Australian Veterinary Journal, EarlyView.
Objective The results of recent faecal egg count reduction tests (FECRTs) were collated to provide an indication of the prevalence and severity of anthelmintic resistance in sheep nematodes across Australia and of changes in comparison to earlier testing reports.
RB Besier, NM Rolls
wiley   +1 more source

Linking molecular architecture to antibacterial functions: a chemical biology view of cyclic depsipeptides. [PDF]

Front Chem
Baravkar S, Thombare VJ, Wu Y, Patil NA.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Cerebral Accumulation of Gadolinium (Gd³⁺) and Related Cellular Stress Pathways in Rat Brain Tissue. [PDF]

Tomography
Tuzcu G, Çildağ B, Çildağ S, Yenisey Ç, Kızılay Z.   +4 more
europepmc   +1 more source

Multi‐Parametric Magnetic Resonance Imaging to Assess Empagliflozin Effect on the Kidneys in People With Type 2 Diabetes Mellitus: A Pilot Clinical Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Empagliflozin is renoprotective in Type 2 diabetes mellitus (T2DM). Our primary aim was to assess empagliflozin's effect on glomerular filtration rate and renal vascular resistance using multiparametric MRI (MpMRI). Our secondary aim was to assess the impact of empagliflozin on additional MpMRI‐derived metrics including markers of tissue ...
Ruth P. Lim, Salma Qassin, Lucy McKenna, Emma Hornsey, Dominic Italiano, Leonid Churilov, Richard J. MacIsaac, Jas‐mine Seah, Elif I. Ekinci, The Austin EMPA‐MRI Study Group   +9 more
wiley   +1 more source

A Fly in the Ointment? Non‐Target Fly Pest Benefits From Reduction in Ivermectin During Targeted Selective Treatment

Entomologia Experimentalis et Applicata, EarlyView.
Targeted Selective Treatment (TST) can reduce the rate of resistance development in livestock gastrointestinal nematodes but can also reduce the effects of anthelmintics on non‐target organisms. Most studies of non‐target anthelmintic effects focus on beneficial species.
Megan J. Lewis, Raphael K. Didham, Jacob D. Berson, Theodore A. Evans   +3 more
wiley   +1 more source