Results 181 to 190 of about 1,721,261 (283)

Flexible receptor architectures for anion recognition <i>via</i> ionic hydrogen bonding. [PDF]

Chem Sci
Prakash A, Sartori AR, Radujević A, Zamkov M, Anzenbacher P.   +4 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Patterns of Anthelmintic Resistance in Gastrointestinal Nematodes of Small Ruminants: A Systematic Review and Meta-Analysis. [PDF]

Vet Sci
Mavundela S, Dzemo WD, Thekisoe O.
europepmc   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Structure-Activity Relationship Analysis of Macrocyclic Peptide RAS Inhibitors: Spotlight on the Solvent-Exposed Region. [PDF]

ACS Med Chem Lett
Chiyoda A, Matsuo A, Yamano T, Tanada M.
europepmc   +1 more source

Pesticide use in integrated pest and pollinator management framework to protect pollinator health

Pest Management Science, Volume 81, Issue 4, Page 1691-1696, April 2025.
Integrated pest management (IPM) emphasizes non‐chemical methods, with pesticides as a last resort, while integrated pest and pollinator management (IPPM) integrates pollinator health into pest control strategies. Abstract Agricultural pesticides have historically been a critical tool in controlling pests and diseases, preventing widespread suffering ...
Ngoc T Phan, David J Biddinger, Edwin G Rajotte, Guy Smagghe, Gadi VP Reddy, Zong‐Xin Ren, Neelendra K Joshi   +6 more
wiley   +1 more source

Flexible molecular chameleons: structural adaptability and therapeutic applications. [PDF]

Front Chem
Bose D, Bhardwaj P, Girigoswami A.
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Hypoxia-responsive supramolecular systems based on macrocycles and self-assembly structures. [PDF]

Med Gas Res
Gabdrakhmanova FB, Churbanova ES, Solovieva SE, Antipin IS.   +3 more
europepmc   +1 more source

Cross‐Scale Engineering of Single‐Atom Catalysts from Local Planar Coordination to Spatial Architectures

Small, EarlyView.
This Review presents a cross‐scale framework for single‐atom catalysts, spanning in‐plane and out‐of‐plane coordination; primary coordination, secondary‐sphere interactions, through‐space microenvironments and support interfaces; individual sites and macroscopic architectures; and static design and directed dynamic reconstruction.
Dazhi Yao, Siheng Yang, Shuhao Wang, Bernt Johannessen, Cheng Tang   +4 more
wiley   +1 more source