Results 171 to 180 of about 20,280 (253)

High‐Resolution LC–MS/MS Characterization of Budmunchiamine‐Type Alkaloids in Albizia niopoides

Rapid Communications in Mass Spectrometry, Volume 40, Issue 19, 15 October 2026.
ABSTRACT Rationale Budmunchiamines are macrocyclic spermine alkaloids that constitute a distinctive class of polyamine natural products predominantly found in species of the genus Albizia. Comprehensive characterization of these compounds remains challenging because of their structural diversity and the limited availability of reference standards. This
Maria L. A. Majevski, Lienne D'Auria Lima, Adriana C. C. Reis, Leonan I. C. R. Santos, Brenno F. S. Vargas, Markus Kohlhoff, Geraldo Célio Brandão   +6 more
wiley   +1 more source

Ribifolones A-H, New Macrocyclic Diterpenes from <i>Jatropha ribifolia</i>, Their Cytotoxic Activity and Insights Supported by Network Pharmacology and Molecular Modeling. [PDF]

Molecules
de Souza TA, Alves AF, de Souza RRM, Albuquerque ACF, Brito TAM, Sobral MV, Dos Santos Júnior FM, Agra MF, Scotti L, Abreu LS, Scotti MT, Tavares JF, da Silva MS.   +12 more
europepmc   +1 more source

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, Volume 46, Issue 5, Page 1362-1389, September 2026.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

Enantioselective Total Synthesis of Two Aromatized Halicyclamines. [PDF]

J Am Chem Soc
Firestone ZD, Grigolo TA, Pernichelle FG, Smith JM.   +3 more
europepmc   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Mapping the inhibition landscape of P-glycoprotein via conformational ensemble docking. [PDF]

Sci Rep
Elbahnsi A, Dragomirescu CD, Palumbo N, Agachi BV, Declèves X, Cisternino S, Isvoran A, Miteva MA.   +7 more
europepmc   +1 more source

Drug Resistance Assessment of Commonly Used Anthelmintics, and Their Combination Effect in Naturally Infected Sheep: The Case of Kaffa Zone, Southwestern Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study evaluated the efficacy of widely used commercial anthelmintics and examined whether combining different drug classes enhances their effectiveness in naturally infected sheep in the Kaffa Zone. This study suggest the presence of emerging anthelmintic resistance to albendazole and tetramisole in the study area and highlight the potential ...
Nahom Belay, Asrat Arke, Lamrot Tesfaye
wiley   +1 more source

Fine-Tuning Side Chain Substitutions: Impacts on the Lipophilicity-Solubility-Permeability Interplay in Macrocyclic Peptides. [PDF]

Mar Drugs
Deng Y, Bian H, Li H, Cui Y, Li S, Li J, Chen L, Zhang X, Shen Z, Li F, Chen Y, Fu H.   +11 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Targeting the H/KRAS α4-β6-α5 Allosteric Lobe with Macrocyclic Peptides. [PDF]

ACS Med Chem Lett
Tran K, Lavoie H, Wahhab A, Garrido D, Jo CH, Poupart MA, Arya T, Beautrait A, Killoran R, Dicaire-Leduc C, Bonneil É, Osborne M, Schuetz DA, Shaikh F, Thibault P, Smith MJ, Marinier A, Therrien M.   +17 more
europepmc   +1 more source