Results 51 to 60 of about 1,721,261 (283)
Advanced Science, EarlyView.Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu +10 more
wiley +1 more source
Synthesis and the Antimicrobial Activity of Salt Carbenoid Compounds
Журнал органічної та фармацевтичної хімії, 2022 Aim. To synthesize aliphatic and aromatic derivatives of salt carbenoid compounds of the series of imidazole, benzimidazole, pyridine, pyrimidine and 1,3,4-oxadiazole containing fluorophenyl, cetyl or adamantyl substituents, and study their antimicrobial
Gennady F. Rayenko +7 more
doaj +1 more source
Advanced Science, EarlyView.Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu +8 more
wiley +1 more source
VIBURNINE, A MACROCYCLIC SPERMIDINE ALKALOID FROM VIBURNUM RHYTIDOPHYLLUM [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 1995 A new macrocyclic spermidine alkaloid; viburnine was isolated from the flowers of Viburnum rhytidophyllum Hessel cultivated in Egypt together with five known compounds; henryoside, salicin, arbutin, catechin and ursolic acid.
Z. Ibraheim, O. Abdallah
doaj +1 more source
Entry point into new trimeric and tetrameric imide-based macrocyclic esters derived from isophthaloyl dichloride and methyl 6-aminonicotinate [PDF]
, 2012 The one-step reaction of isophthaloyl dichloride with the 2-aminopyridine derivative (methyl 6-aminonicotinate) yields (i) a trimer-based macrocycle (EsIO)3 and (ii) a tetramer-based macrocycle (EsIO)4 in modest isolated synthetic yields (total of 25 ...
Gallagher, John F. +3 more
core +2 more sources
, 2022 Edgeworthianins A–E (1–5) were isolated from Edgeworthia chrysantha as a class of macrocyclic daphnane orthoesters with an unusual macrocyclic ring formed from a C14 aliphatic chain.
Wei Li (7081) +6 more
core +1 more source
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Angewandte Chemie, EarlyView.Azamacrocycles provide a tunable platform for rapid N‐carboxyanhydride (NCA) Ring‐Opening Polymerization (ROP). Changing the methylation pattern switches the macrocycle from an external catalyst (N14Me3) to a covalent initiator‐catalyst (IniCat, N14Me1), delivering controlled polypeptide growth under open‐vessel conditions.
Paulina Maksym +10 more
wiley +2 more sources
Acta et Commentationes: Ştiinţe Exacte şi ale NaturiiThe new 15-dentate macrocyclic Schiff base ligand, derived from 2,6-diacetylpyridine and malonic acid dihydrazide, was synthesized using a template condensation approach.
Olga Danilescu +4 more
doaj +1 more source
Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates
Molecules, 2020 As important cancer therapeutic agents, macrocyclic peptides have recently drawn great attention, mainly because they are synthetically accessible and have lower toxicity towards normal cells.
Mohamed H. Abo-Ghalia +5 more
doaj +1 more source