Results 31 to 40 of about 20,280 (253)

Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer

Frontiers in Pharmacology, 2020
BackgroundMultidrug resistance (MDR) has been regarded as one of the major hurdles for the successful outcome of cancer chemotherapy. The collateral sensitivity (CS) effect is one the most auspicious anti-MDR strategies.
Mariana Alves Reis, Ana M. Matos, Noélia Duarte, Omar Bauomy Ahmed, Ricardo J. Ferreira, Ricardo J. Ferreira, Hermann Lage, Maria-José U. Ferreira   +7 more
doaj   +1 more source

Azobenzene's Cross‐Scale Optics and Photonics: Molecular Photoswitching, Mesoscopic Material Motions, and Adaptive Devices

Advanced Materials, EarlyView.
Azobenzene photoswitches translate molecular‐scale E/Z photoisomerization into macroscopic material responses and device‐level photonic functions. This Review highlights how azobenzene research has evolved from molecular photochemistry to photoalignment, mass migration, photomechanics, and heat release, ultimately enabling holography, reconfigurable ...
Heeju Son, Soyul Kwak, Heerin Noh, Minsang Kim, Doyeon Noh, Subhayan Chakraborty, Jaewon Lee, YongDeok Cho, Kyeongsoo Kim, Taewoong Eom, Moonyoung Kim, Jangwon Kim, Hoyoung Lee, Soyoung Lee, Jaehun Kim, Grace G. D. Han, Shin‐Tson Wu, Stefano Oscurato, Arri Priimagi, Marina Saphiannikova, Seungwoo Lee   +20 more
wiley   +1 more source

Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles

Acta Chimica Slovenica, 2021
Synthesis of macrocylic enones starting from alkyl ether and triazole as a linker was achieved using click reaction and intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar
Avula Sri Nivas, Enugala Kalyan Rao
doaj   +1 more source

Bis‐Naphthyl Dipicolinic Dicarboxamide‐Based Self‐Assembled Aqueous Nano Dispersion as an Efficient Light Harvesting Medium and Cucurbit[7]Uril Host Complexation Effect Study

Advanced Optical Materials, EarlyView.
Bis‐naphthyl‐4‐hydroxy‐dipicolinic‐dicarboxamide, a small molecule, forms nanodispersion as an efficient light‐harvesting medium in aqueous solution. Further cucurbit[7]uril addition was found to inhibit the FRET co‐assembly by host‐guest complexation. ABSTRACT Development of artificial light harvesting systems in a minimalistic self‐assembly model is ...
Tumpa Gorai, Abinash Dalai, Thorfinnur Gunnlaugsson   +2 more
wiley   +1 more source

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, EarlyView.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +2 more sources

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Divergent Synthesis of Möbius and Hückel N‐Heterocycloarenes From a Common Macrocyclic Backbone

Angewandte Chemie, EarlyView.
In the divergent synthesis of Möbius and Hückel N‐heterocycloarenes from a common macrocyclic precursor, the annulation reaction dictates topology: Scholl reaction gives Möbius topology, while InCl3‐mediated alkyne annulation gives Hückel topology. The Möbius N‐heterocycloarene is unevenly contorted as revealed by crystal structure, and the Hückel N ...
Han Chen, Huishu Ma, Daiyue Yang, Zheng Zhou, Xiao Chen, Zhifeng Huang, Qian Miao   +6 more
wiley   +2 more sources

A Review of On-Surface Synthesis and Characterization of Macrocycles

Nanomaterials
Macrocyclic organic nanostructures have emerged as crucial components of functional supramolecular materials owing to their unique structural and chemical features, such as their distinctive “infinite” cyclic topology and tunable topology-dependent ...
Chao Yan, Yiwen Wang, Jiahui Li, Xiaorui Chen, Xin Zhang, Jianzhi Gao, Minghu Pan   +6 more
doaj   +1 more source

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

Molecules, 2016
Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses ...
Dongsheng Fan, Guo-Yuan Zhu, Ting Li, Zhi-Hong Jiang, Li-Ping Bai   +4 more
doaj   +1 more source

Mechanically interlocked molecular architectures of valinomycin as cancer targeted prodrugs

Nano Select, 2022
Macrocyclic drugs are promising agents for treating a variety of diseases. However, these compounds usually present delivery limitations, such as low tissue selectivity and poor cellular uptake, which may impair efficacy and clinical translation.
Yoshihiro Tachihara, Yasuhiro Nakagawa, Takuya Miyazaki, Yasutaka Anraku, Horacio Cabral   +4 more
doaj   +1 more source