Results 31 to 40 of about 1,721,261 (283)
Synthetic macrocyclic Ionophores [PDF]
, 1989 14-Crown-4 derivatives bearing either one or two oxymethyl, benzyl- oxymethyl, methoxycarbonylmethyl or carbamoylmethyl substituents have been prepared in an attempt to obtain selective ionophores for lithiumions. Complexation has been monitored by IR,
Nicholson, Patrick Edmund
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Molecules, 2021 Numerous chemical compounds of high practical importance, such as drugs, fertilizers, and food additives are being commercialized as racemic mixtures, although in most cases only one of the isomers possesses the desirable properties. As our understanding
Róbert Berkecz +3 more
doaj +1 more source
Topologically Controlled Synthesis of Reversible Macrocyclic Compounds in Microemulsions
, 2019 A novel and simple approach was used to synthesize a reversible macrocyclic compound. This approach is based on capturing molecules with a photodynamic covalent bond inside microemulsions as nanoreactors and exposing them to UV radiation to facilitate a ...
Rico F. Tabor (1275855) +3 more
core +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway
Toxins, 2020 Macrocyclic trichothecenes are an important group of trichothecenes bearing a large ring. Despite the fact that many of trichothecenes are of concern in agriculture, food contamination, health care and building protection, the macrocyclic ones are ...
Muzi Zhu +4 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
, 2016 The desymmetrization of cyclic anhydrides is carried out using dihydroxy compounds. A mild route to synthesize fused saturated/unsaturated macrocyclic tetralactones with different ring sizes (20−34) having a wide variety of spacers is described.
Boopathy Gnanaprakasam (2230753) +2 more
core +3 more sources
Advanced Functional Materials, EarlyView.Inspired by metal‐free carbonic anhydrases (CAs) that achieve efficient catalysis without metal cofactors, we herein report a sequence‐defined supramolecular peptoid platform that mimics metal‐free CAs and exhibits hydrolytic activity via a supramolecular assembly‐mediated proton‐transfer mechanism.
Progyateg Chakma +8 more
wiley +1 more source
Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer
Frontiers in Pharmacology, 2020 BackgroundMultidrug resistance (MDR) has been regarded as one of the major hurdles for the successful outcome of cancer chemotherapy. The collateral sensitivity (CS) effect is one the most auspicious anti-MDR strategies.
Mariana Alves Reis +7 more
doaj +1 more source