Results 11 to 20 of about 25,151 (288)

Synthesis and Characterization of Complex Compounds of Tetra-aza Macrocyclic Ligand [PDF]

E-Journal of Chemistry, 2008
This paper deals with the synthesis and characterization of a macrocyclic ligand (L) and its new-fangled complex compounds of the general formula [M-L Cl2] for M= Ru(III), and [M-L] for Pt(II) and Pd(II) where L is a macrocyclic ligand resulted from the ...
Mayura A. Panchbhai, L. J. Paliwal, N. S. Bhave   +2 more
doaj   +2 more sources

Validating Small-Molecule Force Fields for Macrocyclic Compounds Using NMR Data in Different Solvents. [PDF]

J Chem Inf Model
Macrocycles are a promising class of compounds as therapeutics for difficult drug targets due to a favourable combination of properties: They often exhibit improved binding affinity compared to their linear counterparts due to their reduced ...
Waibl F, Casagrande F, Dey F, Riniker S.
europepmc   +2 more sources

Editorial: Design of Macrocyclic Compounds for Biomedical Applications. [PDF]

Front Chem, 2021
Padnya PL, Wu X, Erxleben A, Braga SS.
europepmc   +5 more sources

Macrocyclic Compounds for Drug and Gene Delivery in Immune-Modulating Therapy. [PDF]

Int J Mol Sci, 2019
For decades, macrocyclic compounds have been widely applied in various fields owing to essential physicochemical properties such as their rigid cyclic structures, geometric dimensions (diameter and height), hydrophobic cavity, and hydrophilic interface ...
Bai H, Wang J, Li Z, Tang G.
europepmc   +2 more sources

The Role of Macrocyclic Compounds as Supramolecular Drug Delivery Systems: A-Review

Chempublish Journal
In recent decades, significant advances in the development of drug delivery systems have unlocked new possibilities for enhancing therapeutic efficacy.
Muhammad Furqon Novryan Saputra, Yesi Nursofia, Indra Lasmana Tarigan   +2 more
doaj   +5 more sources

Supramolecular Organocatalysis in Water Mediated by Macrocyclic Compounds. [PDF]

Front Chem, 2018
In the last decades many efforts have been devoted to design supramolecular organocatalysts able to work in water as the reaction medium. The use of water as solvent provides promising benefits with respect to environmental impact. In this context, macrocyclic compounds played a role of primary importance thanks to their ease of synthesis and their ...
De Rosa M, La Manna P, Talotta C, Soriente A, Gaeta C, Neri P.   +5 more
europepmc   +6 more sources

Two-Step Synthesis of Complex Artificial Macrocyclic Compounds. [PDF]

Angew Chem Int Ed Engl, 2017
AbstractThe design and synthesis of head‐to‐tail linked artificial macrocycles using the Ugi‐reaction has been developed. This synthetic approach of just two steps is unprecedented, short, efficient and works over a wide range of medium (8–11) and macrocyclic (≥12) loop sizes. The substrate scope and functional group tolerance is exceptional.
Madhavachary R, Abdelraheem EMM, Rossetti A, Twarda-Clapa A, Musielak B, Kurpiewska K, Kalinowska-Tłuścik J, Holak TA, Dömling A.   +8 more
europepmc   +6 more sources

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands. [PDF]

Sci Adv, 2019
Macrocyclic compounds are an attractive modality for drug development, but the limited availability of large, structurally diverse macrocyclic libraries hampers the discovery of leads.
Kale SS, Bergeron-Brlek M, Wu Y, Kumar MG, Pham MV, Bortoli J, Vesin J, Kong XD, Machado JF, Deyle K, Gonschorek P, Turcatti G, Cendron L, Angelini A, Heinis C.   +14 more
europepmc   +2 more sources

Platinum(II) complexes of mixed-valent radicals derived from cyclotricatechylene, a macrocyclic tris-dioxolene [PDF]

, 2015
Three complexes of cyclotricatechylene (H6ctc), [{PtL}3(μ3-ctc)], have been synthesised: (L = 1,2-bis(diphenylphosphino)benzene {dppb}, 1; L = 1,2-bis(diphenylphosphino)ethane {dppe}, 2; L = 4,4′-bis(tert-butyl)-2,2′-bipyridyl {tBu2bipy}, 3).
Sproules, Stephen, Baldansuren, Amgalanbaatar, Hardie, M., Patmore, Nathan J., Hardie, Michaele J., Baldansuren, A., Halcrow, M., Fielding, Alistair John, Loughrey, Jonathan J., Patmore, Nathan John, Loughrey, J.J., Fielding, A.J., Hardie, MJ, Fielding, Alistair J., Halcrow, Malcolm A., Patmore, NJ, Sproules, S, McInnes, Eric J. L., Mcinnes, Eric J L, Loughrey, JJ, Fielding, AJ, Baldansuren, A, Halcrow, MA, Hardie, Michaele, Halcrow, Malcolm, McInnes, EJL, Sproules, S., Patmore, N.J.   +27 more
core   +1 more source

Design, Properties and Recent Application of Macrocycles in Medicinal Chemistry

CHIMIA, 2017
Macrocyclic compounds have recently received increasing attention in drug discovery as these compounds offer the potential to modulate difficult targets and to access novel chemotypes.
Philipp Ermert
doaj   +1 more source