Synthesis and Characterization of Complex Compounds of Tetra-aza Macrocyclic Ligand [PDF]
E-Journal of Chemistry, 2008 This paper deals with the synthesis and characterization of a macrocyclic ligand (L) and its new-fangled complex compounds of the general formula [M-L Cl2] for M= Ru(III), and [M-L] for Pt(II) and Pd(II) where L is a macrocyclic ligand resulted from the ...
Mayura A. Panchbhai +2 more
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The Role of Macrocyclic Compounds as Supramolecular Drug Delivery Systems: A-Review [PDF]
Chempublish JournalIn recent decades, significant advances in the development of drug delivery systems have unlocked new possibilities for enhancing therapeutic efficacy.
Muhammad Furqon Novryan Saputra +2 more
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Macrocyclic Compounds for Drug and Gene Delivery in Immune-Modulating Therapy. [PDF]
Int J Mol Sci, 2019 For decades, macrocyclic compounds have been widely applied in various fields owing to essential physicochemical properties such as their rigid cyclic structures, geometric dimensions (diameter and height), hydrophobic cavity, and hydrophilic interface ...
Bai H, Wang J, Li Z, Tang G.
europepmc +2 more sources
Validating Small-Molecule Force Fields for Macrocyclic Compounds Using NMR Data in Different Solvents. [PDF]
J Chem Inf ModelMacrocycles are a promising class of compounds as therapeutics for difficult drug targets due to a favourable combination of properties: They often exhibit improved binding affinity compared to their linear counterparts due to their reduced ...
Waibl F, Casagrande F, Dey F, Riniker S.
europepmc +4 more sources
Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands. [PDF]
Sci Adv, 2019 Macrocyclic compounds are an attractive modality for drug development, but the limited availability of large, structurally diverse macrocyclic libraries hampers the discovery of leads.
Kale SS +14 more
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Macrocyclic compounds derived from Perfluoro-4-isopropylpyridine [PDF]
, 2001 PerflLioro-4-isopropylpyridine (1) has been shown to undergo nucleophilic substitution reactions with wide range of nucleophiles and was thus demonstrated to behave as a powerful regioselective electrophile in most cases.(INSERT DIAGRAM) This work has ...
Richmond, Paul
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Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development. [PDF]
Angew Chem Int Ed EnglStrategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Sharma KK +5 more
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Design, Properties and Recent Application of Macrocycles in Medicinal Chemistry
CHIMIA, 2017 Macrocyclic compounds have recently received increasing attention in drug discovery as these compounds offer the potential to modulate difficult targets and to access novel chemotypes.
Philipp Ermert
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Frontiers in Chemistry, 2020 Macrocyclic amphiphiles, a type of amphiphiles synthesized based on macrocyclic compounds, have attracted much attention over the past decades due to their unique superiority in the construction of various functional nanomaterials.
Pi Wang, Ruihuan Wang, Danyu Xia
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Molecules, 2022 Novel thiacalix[4]arene based ammonium ionic liquids (ILs) containing amino acid residues (glycine and L-phenylalanine) in cone, partial cone, and 1,3-alternate conformations were synthesized by alkylation of macrocyclic tertiary amines with N ...
Olga Terenteva +4 more
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