Results 41 to 50 of about 25,151 (288)

Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer

Frontiers in Pharmacology, 2020
BackgroundMultidrug resistance (MDR) has been regarded as one of the major hurdles for the successful outcome of cancer chemotherapy. The collateral sensitivity (CS) effect is one the most auspicious anti-MDR strategies.
Mariana Alves Reis, Ana M. Matos, Noélia Duarte, Omar Bauomy Ahmed, Ricardo J. Ferreira, Ricardo J. Ferreira, Hermann Lage, Maria-José U. Ferreira   +7 more
doaj   +1 more source

Designed Lewis Acid–Base Passivation for High Performance Perovskite Solar Cells

Advanced Functional Materials, EarlyView.
ABSTRACT Silicon's high cost and long energy payback time remain major barriers to the global expansion of solar power. In contrast, metal–halide perovskites offer abundant, solution‐processable absorbers, and have achieved efficiencies of 25%–30%, positioning them as strong competitors to silicon.
Afna Manaf, Hiba Shahulhameed, Bhabani Sankar Swain, Shengzhong (Frank) Liu, Adel Najar   +4 more
wiley   +1 more source

Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles

Acta Chimica Slovenica, 2021
Synthesis of macrocylic enones starting from alkyl ether and triazole as a linker was achieved using click reaction and intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar
Avula Sri Nivas, Enugala Kalyan Rao
doaj   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

Azaporphyrinoid‐Based Photo‐ and Electroactive Architectures for Advanced Functional Materials

Advanced Materials, EarlyView.
A long‐standing collaboration between the Torres and Guldi groups has yielded diverse azaporphyrinoid‐based donor‐acceptor nanohybrids with promising applications in solar energy conversion. This conspectus highlights key molecular platforms and structure‐function relationships that govern light and charge management, supporting the rational design of ...
Jorge Labella, Kobra Azizi, Dirk M. Guldi, Tomás Torres   +3 more
wiley   +1 more source

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

Molecules, 2016
Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses ...
Dongsheng Fan, Guo-Yuan Zhu, Ting Li, Zhi-Hong Jiang, Li-Ping Bai   +4 more
doaj   +1 more source

Mechanically interlocked molecular architectures of valinomycin as cancer targeted prodrugs

Nano Select, 2022
Macrocyclic drugs are promising agents for treating a variety of diseases. However, these compounds usually present delivery limitations, such as low tissue selectivity and poor cellular uptake, which may impair efficacy and clinical translation.
Yoshihiro Tachihara, Yasuhiro Nakagawa, Takuya Miyazaki, Yasutaka Anraku, Horacio Cabral   +4 more
doaj   +1 more source

Topologically Controlled Synthesis of Reversible Macrocyclic Compounds in Microemulsions

, 2019
A novel and simple approach was used to synthesize a reversible macrocyclic compound. This approach is based on capturing molecules with a photodynamic covalent bond inside microemulsions as nanoreactors and exposing them to UV radiation to facilitate a ...
Rico F. Tabor (1275855), Toby D. M. Bell (731563), Kei Saito (131742), Yanallah Alqarni (6869606)   +3 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

VIBURNINE, A MACROCYCLIC SPERMIDINE ALKALOID FROM VIBURNUM RHYTIDOPHYLLUM [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1995
A new macrocyclic spermidine alkaloid; viburnine was isolated from the flowers of Viburnum rhytidophyllum Hessel cultivated in Egypt together with five known compounds; henryoside, salicin, arbutin, catechin and ursolic acid.
Z. Ibraheim, O. Abdallah
doaj   +1 more source