Results 131 to 140 of about 103,280 (234)

Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication

open access: yesAngewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Shewanella oneidensis and Bacillus subtilis, both harboring prophages, reveal a novel biosynthetic route to scalable and programmable DNA superstructures in flower‐ and wire‐like shapes, respectively. Activation of prophages is achieved via 3‐hour starvation and monitored using reporter strains.
Gabriel Antonio S. Minero   +7 more
wiley   +2 more sources

Crowder‐specific modulation of hepatitis C virus NS3/4A protease activity and local structural dynamics

open access: yesProtein Science, Volume 35, Issue 11, November 2026.
Abstract Macromolecular crowding modulates enzyme behavior in crowder‐ and protein‐specific ways, yet its impact on viral proteases, which are often key therapeutic targets, remains unclear. Here, we investigated the hepatitis C virus NS3/4A protease under increasing concentrations of polyethylene glycols (PEGs), ficoll, dextran, and lysozyme using ...
Małgorzata Lobka, Joanna Trylska
wiley   +1 more source

Degradable Alternating Copolymers With Strained Cyclobutane Backbones via Photocontrolled RAFT Polymerization

open access: yesAngewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A photocontrolled RAFT strategy enables the alternating copolymerization of 1,3‐disubstituted bicyclo[1.1.0]butanes with electron‐deficient comonomers, affording well‐defined copolymers bearing strained cyclobutane backbones. A high degree of alternation, tunable molecular weights, and excellent end‐group fidelity are achieved through a CTA‐mediated ...
Xia Hu   +4 more
wiley   +2 more sources

Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics

open access: yesChemBioChem, Volume 27, Issue 20, 28 October 2026.
This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Neil Taylor   +2 more
wiley   +1 more source

Encoding Cell‐Surface Receptor Function Through Glycosylation: Lessons From CD44

open access: yesChemBioChem, Volume 27, Issue 19, 14 October 2026.
CD44 function is not solely determined by its protein sequence, it is dynamically encoded by its glycosylation state. Glycan remodeling generates distinct functional receptor states that regulate ligand recognition, receptor organization, lectin interactions, and signaling.
María Payá‐García   +7 more
wiley   +1 more source

Probing macromolecular crowding at the lipid membrane interface with genetically-encoded sensors. [PDF]

open access: yesProtein Sci, 2023
Löwe M   +5 more
europepmc   +1 more source

Protein‐Independent Liquid–Liquid Phase Separation of Adenosine Triphosphate Under Crowded Conditions

open access: yesChemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
ATP itself is able to undergo liquid–liquid phase separation in the presence of the macromolecular crowding agent PEG and physiological ATP concentrations are sufficient for phase separation in the presence of mM Mg2+ and crowders, mimicking intracellular conditions.
Robert Dec   +2 more
wiley   +1 more source

Macromolecular Crowding as a Regulator of Transcription

open access: yesBiomedical Optics 2014, 2014
Inspired by PWS experiments showing cell nanostructural changes in early carcinogenesis, we developed models to study changes in transcription due to macromolecular crowding.
openaire   +2 more sources

Atomic Force Microscopy Imaging of DNA under Macromolecular Crowding Conditions

open access: yes, 2016
Studying the influence of macromolecular crowding at high ionic strengths on assemblies of biomolecules is of particular interest because these are standard intracellular conditions. However, up to now, no techniques offer the possibility of studying the
Loïc Hamon (75173)   +7 more
core   +1 more source

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