Results 111 to 120 of about 228,358 (272)

Antibody binding reports spatial heterogeneities in cell membrane organization

Nature Communications, 2023
The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane.
Daniel P. Arnold, Yaxin Xu, Sho C. Takatori   +2 more
doaj   +1 more source

Corrigendum to "In vitro and in vivo assessment of a non-animal sourced chitosan scaffold loaded with xeno-free umbilical cord mesenchymal stromal cells cultured under macromolecular crowding conditions" [Biomaterials and Biosystems, Volume 16, December 2024, 100102]. [PDF]

Biomater Biosyst
Nubila AD, Doulgkeroglou MN, Gurdal M, Korntner SH, Zeugolis DI.   +4 more
europepmc   +2 more sources

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Macromolecular Crowding of Lipocalins

The FASEB Journal, 2007
Lipocalins are a family of proteins with a tertiary structure of a beta barrel core with alpha‐helices external to the barrel core and normally two disulfide bonds. The lipocalins are an important small molecule binding protein. The lipocalins can be very diverse in overall amino acid sequence (<40%sequence homology) just maintaining core amino ...
openaire   +1 more source

Degradable Alternating Copolymers With Strained Cyclobutane Backbones via Photocontrolled RAFT Polymerization

Angewandte Chemie, EarlyView.
A photocontrolled RAFT strategy enables the alternating copolymerization of 1,3‐disubstituted bicyclo[1.1.0]butanes with electron‐deficient comonomers, affording well‐defined copolymers bearing strained cyclobutane backbones. A high degree of alternation, tunable molecular weights, and excellent end‐group fidelity are achieved through a CTA‐mediated ...
Xia Hu, Hongsik Kim, Lianqian Wu, Yi Jiang, Tae‐Lim Choi   +4 more
wiley   +2 more sources

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Macromolecular crowding effects in crowded biomolecular environments

, 2018
In dieser Arbeit werden Computer-Simulationen eingesetzt um den Einfluss biologisch relevanter, konzentrierter Umgebungen auf das strukturelle Gleichgewicht von (Bio-)Polymeren zu untersuchen. Für diese Simulationen wird ein zuvor beschriebener Monte Carlo Algorithmus verwendet, welcher die Flexibilität der Moleküle anhand von strukturellen Ensembles ...
openaire   +3 more sources

Macromolecular Crowding as a Cell VolumeSensor

Cellular Physiology and Biochemistry, 2000
The non-ideal properties of solutions containing high concentrations of macromolecules can result in enormous increases in the activity of the individual macromolecules. There is considerable evidence that macromolecular crowding and confinement not only occur in cells, but that these are major determinants of the activity of the proteins and other ...
openaire   +2 more sources

Localization of protein aggregation in Escherichia coli is governed by diffusion and nucleoid macromolecular crowding effect. [PDF]

PLoS Computational Biology, 2013
Aggregates of misfolded proteins are a hallmark of many age-related diseases. Recently, they have been linked to aging of Escherichia coli (E. coli) where protein aggregates accumulate at the old pole region of the aging bacterium.
Anne-Sophie Coquel, Jean-Pascal Jacob, Mael Primet, Alice Demarez, Mariella Dimiccoli, Thomas Julou, Lionel Moisan, Ariel B Lindner, Hugues Berry   +8 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source