Results 231 to 240 of about 228,358 (272)
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Advanced Healthcare Materials, 2021
Scaffolds for tissue engineering aim to mimic the native extracellular matrix (ECM) that provides physical support and biochemical signals to modulate multiple cell behaviors.
Cheng-En Chiang +7 more
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Scaffolds for tissue engineering aim to mimic the native extracellular matrix (ECM) that provides physical support and biochemical signals to modulate multiple cell behaviors.
Cheng-En Chiang +7 more
semanticscholar +1 more source
Journal of Physical Chemistry Letters, 2022
Macromolecular crowding has a profound impact on the conformational dynamics and intermolecular interactions of biological macromolecules. In this context, the role of inert synthetic crowders in the protein-protein interactions of globular proteins is ...
Chinmaya Kumar Patel +3 more
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Macromolecular crowding has a profound impact on the conformational dynamics and intermolecular interactions of biological macromolecules. In this context, the role of inert synthetic crowders in the protein-protein interactions of globular proteins is ...
Chinmaya Kumar Patel +3 more
semanticscholar +1 more source
Macromolecular Crowding and Protein Stability
Journal of the American Chemical Society, 2012An understanding of cellular chemistry requires knowledge of how crowded environments affect proteins. The influence of crowding on protein stability arises from two phenomena, hard-core repulsions and soft (i.e., chemical) interactions. Most efforts to understand crowding effects on protein stability, however, focus on hard-core repulsions, which are ...
Yaqiang, Wang +4 more
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Macromolecular crowding agents enhance the sensitivity of lateral flow immunoassays.
Biosensors & bioelectronics, 2022Lateral flow immunoassays (LFIA) have a plethora of applications in health, environmental and food sectors for low-cost, simple, and rapid point-of-need testing.
Natalia-Maria Christopoulou +2 more
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Physical Chemistry, Chemical Physics - PCCP, 2022
The cellular environment is crowded by macromolecules of various sizes, shapes, and charges, which modulate protein structure, function and dynamics. Herein, we contemplated the effect of three different macromolecular crowders: dextran-40, Ficoll-70 and
Nilimesh Das, P. Sen
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The cellular environment is crowded by macromolecules of various sizes, shapes, and charges, which modulate protein structure, function and dynamics. Herein, we contemplated the effect of three different macromolecular crowders: dextran-40, Ficoll-70 and
Nilimesh Das, P. Sen
semanticscholar +1 more source
Macromolecular Crowding and Its Consequences
1999Incompatible pairs of polymers separate into two phases in aqueous solution above a few percentage points total concentration. Protein pairs can also produce phase separation, but at somewhat higher concentrations. In this chapter, we explore the effect of high background concentrations of macromolecules on phase separation of pairs of species which ...
H O, Johansson, D E, Brooks, C A, Haynes
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Bioinspired in vitro microenvironments to control cell fate: Focus on macromolecular crowding.
American Journal of Physiology - Cell Physiology, 2021The development of therapeutic regenerative medicine and accurate drug discovery cell-based products requires effective, with respect to obtaining sufficient numbers of viable, proliferative and functional cell populations, cell expansion ex vivo ...
D. Zeugolis
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Activity of Subtilisin Carlsberg in macromolecular crowding
Journal of Photochemistry and Photobiology B: Biology, 2007Enzymatic activity of a proteolytic enzyme Subtilisin Carlsberg (SC) in anionic sodium dodecyl sulfate (SDS) micellar medium has been explored and found to be retarded compared to that in bulk buffer. Circular dichroism (CD) study reveals that SDS, which is a potential protein denaturant, has an insignificant denaturation effect on SC.
Ajay Kumar, Shaw, Samir Kumar, Pal
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An early look at macromolecular crowding
Biophysical Chemistry, 1995Interest in the interaction between proteins and polysaccharides in semidilute systems developed in the late 1950's and early 1960's both in the field of matrix biology and in the construction of new separation techniques. The author gives an account of how his work in the 50's on the characterization of a connective tissue polysaccharide, hyaluronan ...
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International Journal of Biological Macromolecules, 2022
Existence of numerous biomolecules results in biological fluids to be extremely crowded. Thus, Macromolecular crowding is an essential phenomenon to sustain active conformation of proteins in biological systems.
Sachin M. Shet +8 more
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Existence of numerous biomolecules results in biological fluids to be extremely crowded. Thus, Macromolecular crowding is an essential phenomenon to sustain active conformation of proteins in biological systems.
Sachin M. Shet +8 more
semanticscholar +1 more source