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Role of Aqueous Media in Macromolecular Crowding
The behavior of biomolecules in a crowded environment is affected by a number of factors, with the excluded volume being traditionally considered as a major contributor to the macromolecular crowding effects in polymer solutions. In addition to the hard nonspecific steric interactions representing the excluded volume effects, other commonly considered ...Pedro P, Madeira +2 more
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Macromolecular Crowding in Cytoplasm and Cellular Organelles
A high concentration of diverse macromolecules causes a densely packed environment, influencing both function and structural change of the cell organelles, cytoplasm, and molecules within. The concept of molecular crowding was for the first time introduced in the 70 s but was only accepted at the end of the 90 s.Muhamed, Adilović +2 more
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Shape matters in macromolecular crowding
C&EN Global Enterprise, 2018In the crowded conditions typical of biological cells, nonspecific interactions can affect macromolecules’ behavior. In theoretical studies of crowding, macromolecules are often treated as sterically repulsive hard spheres, with no consideration of the actual shape of the molecules.
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The Role of Macromolecular Crowding in Cytoskeletal Organization
The cytoskeleton is not only responsible for cell morphology and rheology, but is also involved in such functions as cell motility, intracellular transport and cell division. Key to all these roles is the suitable deployment of its labile parts, a process that occurs in a highly crowded environment.openaire +2 more sources
Macromolecular Crowding in Cell Stress and Death
To study macromolecular crowding (MC) in living cells, one needs a method to measure it. Several existing approaches to quantify MC address slightly different aspects of crowding. If we define MC through protein concentration, it can be measured by quantitative phase imaging coupled with volume determination; both can be realized on a standard bright ...openaire +2 more sources
Macromolecular Crowding Enhances the Detection of DNA and Proteins by a Solid-State Nanopore
Nano Letters, 2020Sheena Radford +2 more
exaly
Unraveling the enthalpy of macromolecular crowding
Biophysical Journal, 2023Claire J. Stewart +3 more
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What Macromolecular Crowding Can Do to a Protein
International Journal of Molecular Sciences, 2014Irina M Kuznetsova +2 more
exaly