Results 201 to 210 of about 228,358 (272)

Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis. [PDF]

Biomacromolecules
Doubková M, Knitlová J, Vondrášek D, Eckhardt A, Novotný T, Ošt'ádal M, Filová E, Bačáková L.   +7 more
europepmc   +1 more source

Harnessing Macromolecular Crowding of Proteins for Engineering Sustainable Nanofiltration Membranes

Claudia Oviedo, Diana Gulyas Oldal, Rifan Hardian, Tibor Höltzl, Maged F. Serag, Satoshi Habuchi, György Székely   +6 more
openalex   +1 more source

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal, Azim Ansari, Mohd Usman Mohd Siddique, Jyotiram Sawale, Suhas Padmane, Raju Wadekar   +5 more
wiley   +1 more source

Contrasting effects of different molecular crowding environments on base‐pair opening/closing dynamics of DNA triplex structures

The FEBS Journal, Volume 293, Issue 16, Page 5067-5083, August 2026.
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto, Yudai Yamaoki, Takashi Nagata, Masato Katahira   +3 more
wiley   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Intracellular Macromolecular Crowding within Individual Stress Fibers Analyzed by Fluorescence Correlation Spectroscopy. [PDF]

Cell Mol Bioeng
Buenaventura A, Saito T, Kanao T, Matsunaga D, Matsui TS, Deguchi S.   +5 more
europepmc   +1 more source

Arabidopsis WSS1A, a DNA‐protein crosslink repair protease, delays leaf senescence in cooperation with SUMO3

The Plant Journal, Volume 127, Issue 4, August 2026.
SUMMARY Leaf senescence, the final stage of leaf development, is regulated by complex interplays of intrinsic genetic programs and environmental cues. Throughout their lifetimes, all living organisms encounter various endogenous and environmental challenges, many of which can cause potentially fatal DNA damage. Among these, DNA‐protein crosslinks (DPCs)
Sanghoon Park, Hyunwoo Oh, Ukcheol Jeong, Jae Ho Lee, Hyeyoung Choi, Hyunsu Park, Jinkwang Kim, Yongmin Kim, Junmin Kwak, Yeong Seon Yoon, Zhonghai Li, Jong‐Chan Lee, Hye Ryun Woo   +12 more
wiley   +1 more source

The effect of macromolecular crowders on deposition of extracellular matrix in astrocyte cultures [PDF]

Sorour Nemati, Michelle Kilcoyne, Dimitrios I. Zeugolis, Siobhán S. McMahon   +3 more
openalex   +1 more source

Role of associated water in stabilizing human γ‐D crystallin under shape‐dependent macromolecular crowding

B. Singh, Pratik Sen
openalex   +2 more sources

Macromolecular Crowding-Affected Mobility of Bcnt/Cfdp1, a Disordered Component of the Srcap Complex, from the Nucleus to Cytosol in Subcellular Fractionation [PDF]

Shintaro Iwashita, Takehiro Suzuki, Kouichi Nishimura, Ayaka Onishi, Kyoka Tsukuda, Yoshito Kakihara, Yoshimitsu Kiriyama, Yoshiharu Ohoka, Kentaro Nakashima   +8 more
openalex   +1 more source