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Macromolecular crowding: Macromolecules friend or foe
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015Cellular interior is known to be densely crowded due to the presence of soluble and insoluble macromolecules, which altogether occupy ~40% of the total cellular volume. This results in altered biological properties of macromolecules.Macromolecular crowding is observed to have both positive and negative effects on protein folding, structure, stability ...
Shruti, Mittal +2 more
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Effects of Macromolecular Crowding on Nuclear Size
Experimental Cell Research, 1995The concentration of macromolecules inside cells is high, and the resultant crowding of cytoplasm can be expected to affect many interactions involving macromolecular assemblies. Here, we have examined the effect of solute size and concentration on nuclear volume in saponin-permeabilized macrophages.
G R, Rosania, J A, Swanson
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Macromolecular crowding effects on protein dynamics
International Journal of Biological MacromoleculesMacromolecular crowding experiments bridge the gap between in-vivo and in-vitro studies by mimicking some of the cellular complexities like high viscosity and limited space, while still manageable for experiments and analysis. Macromolecular crowding impacts all biological processes and is a focus of contemporary research.
Nilimesh Das +2 more
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Implications of macromolecular crowding for protein assembly
Current Opinion in Structural Biology, 2000Recent studies have led to increased appreciation of the influence of excluded volume in solutions of high total macromolecular content ('macromolecular crowding') upon the various classes of reaction that lead to the assembly of proteins and protein complexes.
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Cytoskeleton, Motile Structures and Macromolecular Crowding
1994We descrive the effect of macromolecular crowding on the associations of the cytoskeletal and of the motile structures. These effects are due to preferential interactions and have been treated theoretically by many authors1,2,3,4. Occasionally, preferential interactions are taken into account in the study of the biological reactions, their role ...
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Macromolecular Crowding in Cytoplasm and Cellular Organelles
A high concentration of diverse macromolecules causes a densely packed environment, influencing both function and structural change of the cell organelles, cytoplasm, and molecules within. The concept of molecular crowding was for the first time introduced in the 70 s but was only accepted at the end of the 90 s.Muhamed, Adilović +2 more
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Role of Aqueous Media in Macromolecular Crowding
The behavior of biomolecules in a crowded environment is affected by a number of factors, with the excluded volume being traditionally considered as a major contributor to the macromolecular crowding effects in polymer solutions. In addition to the hard nonspecific steric interactions representing the excluded volume effects, other commonly considered ...Pedro P, Madeira +2 more
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The Role of Macromolecular Crowding in Cytoskeletal Organization
The cytoskeleton is not only responsible for cell morphology and rheology, but is also involved in such functions as cell motility, intracellular transport and cell division. Key to all these roles is the suitable deployment of its labile parts, a process that occurs in a highly crowded environment.openaire +2 more sources
Macromolecular Crowding in Cell Stress and Death
To study macromolecular crowding (MC) in living cells, one needs a method to measure it. Several existing approaches to quantify MC address slightly different aspects of crowding. If we define MC through protein concentration, it can be measured by quantitative phase imaging coupled with volume determination; both can be realized on a standard bright ...openaire +2 more sources