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Modulating peptide co-assembly via macromolecular crowding: Recipes for co-assembled structures
Xin Dong +3 more
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Macromolecular crowding sensing during osmotic stress in plants
Trends in Biochemical SciencesOsmotic stress conditions occur at multiple stages of plant life. Changes in water availability caused by osmotic stress induce alterations in the mechanical properties of the plasma membrane, its interaction with the cell wall, and the concentration of ...
Cesar Cuevas-Velazquez +2 more
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Regenerative medicine relies on tissue engineering to create functional tissue constructs that can repair or replace damaged organs. This process requires both structural support, such as physical scaffolds, cell adhesion sites, and spatial organization ...
Bitan Guchhait +3 more
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Macromolecular crowding effects on protein dynamics.
International Journal of Biological MacromoleculesMacromolecular crowding experiments bridge the gap between in-vivo and in-vitro studies by mimicking some of the cellular complexities like high viscosity and limited space, while still manageable for experiments and analysis.
Nilimesh Das +4 more
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Macromolecular Crowding by Polyethylene Glycol Reduces Protein Breathing.
Journal of Physical Chemistry Letters, 2023Most efforts to understand macromolecular crowding focus on global (i.e., complete) unfolding, but smaller excursions, often called breathing, promote aggregation, which is associated with several diseases and the bane of pharmaceutical and commercial ...
I. Chu +3 more
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Macromolecular crowding: obvious but underappreciated
Trends in Biochemical Sciences, 2001Biological macromolecules evolve and function within intracellular environments that are crowded with other macromolecules. Crowding results in surprisingly large quantitative effects on both the rates and the equilibria of interactions involving macromolecules, but such interactions are commonly studied outside the cell in uncrowded buffers.
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International Journal of Biological Macromolecules, 2023
Macromolecular crowding can change kinetics of enzyme catalysis. How interaction between enzymes and neighboring macromolecules contributes to the crowding effect on enzyme catalysis has not been quantitatively revealed.
Siyuan Xu, Jie Wang, Jian Dong
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Macromolecular crowding can change kinetics of enzyme catalysis. How interaction between enzymes and neighboring macromolecules contributes to the crowding effect on enzyme catalysis has not been quantitatively revealed.
Siyuan Xu, Jie Wang, Jian Dong
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Macromolecular dynamics in crowded environments
The Journal of Chemical Physics, 2010The structural and dynamical properties of macromolecules in confining or crowded environments are different from those in simple bulk liquids. In this paper, both the conformational and diffusional dynamics of globular polymers are studied in solutions containing fixed spherical obstacles.
Carlos, Echeverria, Raymond, Kapral
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