Results 101 to 110 of about 141,802 (323)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Acute physiological effects on macromolecule digestion following oral ingestion of the enzyme blend Elevase® in individuals that had undergone an ileostomy, but were otherwise healthy—a randomized, double blinded, placebo-controlled exploratory study

Frontiers in Nutrition
Digestive enzymes can selectively degrade proteins, carbohydrates and lipids; and their supplementation alongside food may accelerate the breakdown of complex food matrices, facilitate greater nutrient absorption, decrease food sensitivities and aid in ...
Shahneela Mazhar, Annie Simon, Joan Colom, Ekaterina Khokhlova, Martin Buckley, Christopher Phipps, John Deaton, Kieran Rea   +7 more
doaj   +1 more source

Capillary Permeability to Macromolecules [PDF]

, 1955
Karlman Wasserman, Leopold Loeb, H. S. Mayerson, Allen H. Mackenzie, Arthur S. Cummins   +4 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Editorial: Microbial Communities and Metabolisms Involved in the Degradation of Cellular and Extracellular Organic Biopolymers

Frontiers in Microbiology, 2022
S. Emil Ruff
doaj   +1 more source

Structure and evolvement of Spirulina platensis Fe-SOD(钝顶螺旋藻Fe-SOD的结构与进化)

Zhejiang Daxue xuebao. Lixue ban, 2005
超氧化物歧化酶（Superoxide dismutase，SOD）是一类重要的具有抗氧化损伤功能的金属酶.利用生物信息学手段，分析了钝顶螺旋藻(Spirulina platensis)Fe-SOD的结构与进化，结合此蛋白的功能，揭示了两者的内在联系：在结构上，此蛋白的中间区城(26 AA~160 AA）结构紧凑，为酶的活性中心，两端区域离活性中心较远；在进化上，此蛋白两端区域较中间区域更倾向于发生突变.并且通过Fe-SOD，首次对以上三者间特殊关系的形成机制进行了猜想与假设.
LUMin(卢敏), QINGui-xiang(秦桂香), GONGXing-guo(龚兴国), GUOJian-jun(郭建军), ZHONGWen-tao(钟文涛)   +4 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

BAND-CENTRIFUGATION OF MACROMOLECULES AND VIRUSES IN SELF-GENERATING DENSITY GRADIENTS [PDF]

, 1963
Jerome Vinograd, Robert Bruner, Rebecca Kent, J. Weigle   +3 more
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A SUBUNIT MODEL FOR THE TROPOCOLLAGEN MACROMOLECULE [PDF]

, 1964
John Petruska, Alan J. Hodge
openalex   +1 more source