Results 41 to 50 of about 1,540,630 (392)
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Nature Communications, 2021 Macrophages perform diverse functions within tissues during immune responses to pathogens and injury, but molecular mechanisms by which physical properties of the tissue regulate macrophage behavior are less well understood.
Hamza Atcha +11 more
semanticscholar +1 more source
Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]
, 2014 The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam +14 more
core +2 more sources
Nature Reviews Immunology, 2016 Macrophages expressing PPARγ support skeletal muscle regeneration by inducing secretion of the myoblast growth factor GDF3.
openaire +3 more sources
Metabolic reprogramming in macrophage responses
Biomarker Research, 2021 Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment ...
Yang Liu +9 more
semanticscholar +1 more source
Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages [PDF]
, 2018 Background: As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophages tightly control the angiogenic
Blandino, Giovanni +14 more
core +3 more sources
The pulmonary macrophage. [PDF]
Environmental Health Perspectives, 1976 An overview of the pulmonary macrophage is provided, with particular emphasis on the origin of this cell and the adaptive mechanisms whereby the macrophagic system is able to respond to increased inhalant loads of organic and inorganic pollutants. Evidence is presented which favors an hematopoietic origin for the alveolar macrophage with a monocytic ...
openaire +2 more sources
Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Nature Reviews Cardiology, 2021 Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies to further reduce the risk of cardiovascular disease.
Wei Chen +5 more
semanticscholar +1 more source
The Metabolic Signature of Macrophage Responses
Frontiers in Immunology, 2019 Macrophages are a heterogeneous population of immune cells playing several and diverse functions in homeostatic and immune responses. The broad spectrum of macrophage functions depends on both heterogeneity and plasticity of these cells, which are highly
A. Viola +4 more
semanticscholar +1 more source
Tailoring Materials for Modulation of Macrophage Fate
Advances in Materials, 2021 Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity and adaptive immunity hold great promise for a broad range of prophylactic and therapeutic ...
Jinhua Li +4 more
semanticscholar +1 more source
MAP kinase phosphatase 2 regulates macrophage-adipocyte interaction. [PDF]
PLoS ONE, 2015 Inflammation is critical for the development of obesity-associated metabolic disorders. This study aims to investigate the role of mitogen-activated protein kinase phosphatase 2 (MKP-2) in inflammation during macrophage-adipocyte interaction.White ...
Huipeng Jiao, Peng Tang, Yongliang Zhang
doaj +1 more source