Results 121 to 130 of about 128,741 (174)

Bacteria‐Derived Extracellular Vesicle as A “Trojan Horse” for Selective M1 Macrophage‐Targeting in A Multi‐Cellular Entanglement Environment

Advanced Functional Materials, EarlyView.
The temporary transition of macrophages from a pro‐inflammatory phenotype of macrophages (M1) to an anti‐inflammatory phenotype of macrophages (M2) is crucial for tissue repair and regeneration processes. Bacterial outer membrane vesicles (OMVs) are utilized as a “trojan horse” for specific M1 macrophage‐targeting and anti‐inflammatory drug delivery ...
Donglin Cai, Zhelun Li, Wendong Gao, Yuqing Mu, Jiaying Liu, Yufeng Zhang, Xiaohan Mei, Jingjing Quan, Lan Xiao, Yin Xiao   +9 more
wiley   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Application of Single-cell Deep Learning in Elucidating the Mapping Relationship Between Visceral and Body Surface Inflammatory Patterns [PDF]

arXiv
As a system of integrated homeostasis, life is susceptible to disruptions by visceral inflammation, which can disturb internal environment equilibrium. The role of body-spread subcutaneous fascia (scFascia) in this process is poorly understood. In the rat model of Salmonella-induced dysentery, scRNA-seq of scFascia and deep-learning analysis revealed ...
arxiv  

Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
This study introduces a novel HCC treatment using poly lactic‐co‐glycolic acid (PLGA) nanoparticles encased in HCC cell membranes to co‐deliver Lenvatinib and FePt nanoparticles. This approach improves treatment efficacy by enhancing ferroptosis and apoptosis.
Feichao Xuan, Xingyang Zhao, Weiran Pang, Zirong Li, Xiangyi Yin, Weizhong Xie, Xiaojun Zeng, Liming Nie, Junying Yang, Shiying Li, Puxiang Lai, Chihua Fang   +11 more
wiley   +1 more source

Biocompatibility of Water‐Dispersible Pristine Graphene and Graphene Oxide Using a Close‐to‐Human Animal Model: A Pilot Study on Swine

Advanced Healthcare Materials, EarlyView.
Graphene‐based materials are attracting considerable interest for biomedical applications. Analysis of their biocompatibility is required before their clinical translation, and swine represents an excellent close‐to‐human model. This study evaluates the toxicological and immunological impact of pristine graphene and graphene oxide through a compendium ...
Paola Nicolussi, Giovannantonio Pilo, Maria Giovanna Cancedda, Guotao Peng, Ngoc Do Quyen Chau, Alejandro De la Cadena, Renzo Vanna, Yarjan Abdul Samad, Tanweer Ahmed, Jeremia Marcellino, Giuseppe Tedde, Linda Giro, Acelya Ylmazer, Federica Loi, Gavina Carta, Loredana Secchi, Silvia Dei Giudici, Simona Macciocu, Dario Polli, Yuta Nishina, Ciriaco Ligios, Giulio Cerullo, Andrea Ferrari, Alberto Bianco, Bengt Fadeel, Giulia Franzoni, Lucia Gemma Delogu   +26 more
wiley   +1 more source

3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization

Advanced Healthcare Materials, EarlyView.
The ability of human induced pluripotent stem cells (hiPSCs) to model developmental processes makes them a promising source for engineering testicular tissues to study in vitro maturation and sperm production. This work describes the first hiPSC‐derived testicular model and shows that it captures functional aspects of prepubertal testicular tissues ...
Meghan A Robinson, Sonia HY Kung, Khaled YM Youssef, Kali M Scheck, Robert H Bell, Funda Sar, Anne M Haegert, M Mahdi Asmae, Changfeng Cheng, Salina V Yeack, Bhairvi T Mathur, Feng Jiang, Colin C Collins, Faraz Hach, Stephanie M Willerth, Ryan K Flannigan   +15 more
wiley   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, EarlyView.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Probiotic‐Based Mineralized Living Materials to Produce Antimicrobial Yogurts

Advanced Healthcare Materials, EarlyView.
The self‐assembly and mineralization of collagen in the presence of probiotics produces hybrid living materials that hosts and protects the cells. Intra‐ and interfibrillar mineralization of collagen fibers, as occurring in bone, results, respectively, in a bulk and single‐cell protective layer of cells, that survive in simulated gastric conditions and,
Gloria B. Ramírez‐Rodríguez, Laura Sabio, Laura Cerezo‐Collado, Víctor Garcés, Jose M. Domínguez‐Vera, José M. Delgado‐López   +5 more
wiley   +1 more source

Immune‐Infiltrated Cancer Spheroid Model with Vascular Recirculation Reveals Temporally Dependent and Tissue‐Specific Macrophage Recruitment

Advanced Healthcare Materials, EarlyView.
The migration and infiltration of circulating monocytes into cancer spheroids are shown using a pumpless recirculating platform. This method allows for the continuous circulation of immune cells, which is essential for observing the long‐term dynamic behavior of immune cells within cancer environments.
Feng Zhang, Kimia Asadi Jozani, Anushree Chakravarty, Dawn Lin, Andrew Hollinger, Shravanthi Rajasekar, Boyang Zhang   +6 more
wiley   +1 more source

Enhanced Bioprinting of 3D Corneal Stroma Patches with Reliability, Assessing Product Consistency and Quality through Optimized Electron Beam Sterilization

Advanced Healthcare Materials, EarlyView.
This study optimizes sterilization methods for bioprinted 3D corneal stroma patches made from cornea‐derived decellularized extracellular matrix (Co‐dECM) hydrogels and human keratocytes. It demonstrates the superiority of electron beam sterilization in preserving the mechanical, biochemical, and immunomodulatory properties of hydrogels, ensuring ...
Jungbin Yoon, Yeon‐ju Lee, Minji Kim, Ju Young Park, Jinah Jang   +4 more
wiley   +1 more source