Results 151 to 160 of about 646,237 (202)

Regulation of macrophage activation

Cellular and Molecular Life Sciences (CMLS), 2003
IFN-gamma rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently undergo a slower classical type 1 activation upon exposure to T helper (Th)1 cytokines such as IFNgamma or other activators, including tumor necrosis factor and lipopolysaccharide, e.g. in intracellular killing of phagocytosed Mycobacterium tuberculosis.
J, Ma, T, Chen, J, Mandelin, A, Ceponis, N E, Miller, M, Hukkanen, G F, Ma, Y T, Konttinen   +7 more
openaire   +2 more sources

Macrophage activation revisited

Immunology Today, 1994
Macrophages are extremely adaptable cells, able to modify their behavior in response to diverse signals from other cells and the extracellular matrix. A recent workshop provided insights into current research on these remarkable cells.
A, Celada, C, Nathan
openaire   +2 more sources

Polarized Activation of Macrophages

2014
Macrophages are mononuclear phagocytes which play important roles in many aspects of immunity, tissue repair and metabolism. Plasticity is a key feature of these cells and consists in the capability to modulate their phenotypic and functional aspects under distinct stimuli derived from the microenvironment. A number of transcription factors, epigenetic
Galdiero, M. R., Biswas, S. K., Mantovani, A.   +2 more
openaire   +2 more sources

Activation of macrophages by neuropeptides

Brain, Behavior, and Immunity, 1988
Macrophages play a key role in the initiation and execution of immunoinflammatory responses. Evidence is reviewed which indicates that neuropeptides are capable of up- or down-regulating their state of activation. Substance P, neurokinin A, neurotensin, bombesin, gastrin-releasing peptide, endorphins, enkephalins, somatotropin, and somatostatin elicit ...
openaire   +2 more sources

Macrophage activation syndrome

Current Opinion in Rheumatology, 2002
Macrophage activation syndrome (MAS) is a serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T lymphocytes and macrophages. Recent findings in hemophagocytic lymphohistiocytosis, a disease that is clinically similar to MAS, highlight the possible pathogenetic role ...
openaire   +3 more sources

Macrophage activation and polarization

Frontiers in Bioscience, 2008
Macrophages are widely distributed immune system cells that play an indispensable role in homeostasis and defense. They can be phenotypically polarized by the microenvironment to mount specific functional programs. Polarized macrophages can be broadly classified in two main groups: classically activated macrophages (or M1), whose prototypical ...
F. O. Martinez, A. Sica, A. Mantovani, M. Locati   +3 more
openaire   +3 more sources

A novel phenotype for an activated macrophage: the type 2 activated macrophage

Journal of Leukocyte Biology, 2002
AbstractActivated macrophages were used as antigen presenting cells (APCs) to determine the extent to which these APCs could influence an adaptive immune response. We show that activated macrophages induced a strong polarized Th1-like T cell response that was predominated by IFN-γ.
Charles F, Anderson, David M, Mosser
openaire   +2 more sources

Alternative activation of macrophages

Nature Reviews Immunology, 2003
The classical pathway of interferon-gamma-dependent activation of macrophages by T helper 1 (T(H)1)-type responses is a well-established feature of cellular immunity to infection with intracellular pathogens, such as Mycobacterium tuberculosis and HIV.
openaire   +2 more sources

Regulators of macrophage activation

European Journal of Immunology, 2011
AbstractMacrophages are ubiquitous phagocytes that can constitute up to 15% of the cellular content of tissues. These heterogeneous cells of the innate immune system perform important functions during health and disease. Equipped with receptors for the T helper cell cytokines INF‐γ and IL‐4, macrophages undergo specific activation programs during Th1 ...
openaire   +2 more sources

Arginine and Macrophage Activation

2011
In order to perform their functions, macrophages must be activated either by Th1-type cytokines, such as interferon-gamma which is called classical activation or M1, or by Th2-type cytokines, such as IL-4, IL-10, IL-13, etc. referred as alternative activation or M2.
Comalada, M., Yeramian, A., Modolell, M., Lloberas, J., Celeba, A.   +4 more
openaire   +3 more sources