Results 251 to 260 of about 645,635 (289)

Activation of macrophages

Comparative Immunology, Microbiology and Infectious Diseases, 1985
The role of macrophages is essential in the development of a normal immune response. Not only are these cells involved in the initiation of this response by presenting antigens to lymphocytes and by producing Interleukin I, but they also participate in the various phenomena of cellular co-operation and regulation.
E, Schneider, M, Dy
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Macrophage activation syndrome

Current Opinion in Rheumatology, 2002
Macrophage activation syndrome (MAS) is a serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T lymphocytes and macrophages. Recent findings in hemophagocytic lymphohistiocytosis, a disease that is clinically similar to MAS, highlight the possible pathogenetic role ...
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Regulation of macrophage activation

Cellular and Molecular Life Sciences (CMLS), 2003
IFN-gamma rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently undergo a slower classical type 1 activation upon exposure to T helper (Th)1 cytokines such as IFNgamma or other activators, including tumor necrosis factor and lipopolysaccharide, e.g. in intracellular killing of phagocytosed Mycobacterium tuberculosis.
J, Ma, T, Chen, J, Mandelin, A, Ceponis, N E, Miller, M, Hukkanen, G F, Ma, Y T, Konttinen   +7 more
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Polarized Activation of Macrophages

2014
Macrophages are mononuclear phagocytes which play important roles in many aspects of immunity, tissue repair and metabolism. Plasticity is a key feature of these cells and consists in the capability to modulate their phenotypic and functional aspects under distinct stimuli derived from the microenvironment. A number of transcription factors, epigenetic
Galdiero, M. R., Biswas, S. K., Mantovani, A.   +2 more
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Macrophage activation and polarization

Frontiers in Bioscience, 2008
Macrophages are widely distributed immune system cells that play an indispensable role in homeostasis and defense. They can be phenotypically polarized by the microenvironment to mount specific functional programs. Polarized macrophages can be broadly classified in two main groups: classically activated macrophages (or M1), whose prototypical ...
F. O. Martinez, A. Sica, A. Mantovani, M. Locati   +3 more
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Activation of macrophages for antimycobacterial activity

Immunology Letters, 1985
The role of macrophage hydrogen peroxide in defense against mycobacterial infection is discussed - not because this is necessarily any more important than other macrophage products (reviews: [1, 2]) but more as a reflection of recently available information.
D B, Lowrie, P S, Jackett, P W, Andrew
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Macrophage Activation Syndrome

Arthritis & Rheumatology
Macrophage activation syndrome (MAS) is a state of immune hyperactivation that can result in life‐threatening multisystem end‐organ dysfunction. Often termed a “cytokine storm,” MAS occurs among the rheumatic diseases most typically in Still's disease but also in systemic lupus erythematosus and Kawasaki disease.
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Arginine and Macrophage Activation

2011
In order to perform their functions, macrophages must be activated either by Th1-type cytokines, such as interferon-gamma which is called classical activation or M1, or by Th2-type cytokines, such as IL-4, IL-10, IL-13, etc. referred as alternative activation or M2.
Comalada, M., Yeramian, A., Modolell, M., Lloberas, J., Celeba, A.   +4 more
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Interferon Activates Macrophages to Produce Plasminogen Activator

Journal of Interferon Research, 1982
Macrophages and monocytes become activated, by a variety of mechanisms, to exhibit cytotoxicity. Associated with this activation for cytotoxicity is the production of certain neutral proteases, especially plasminogen activator (PA), which may be involved in the mechanism of cytolysis.
C M, Jones, L, Varesio, R B, Herberman, S, Pestka   +3 more
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Mycobacteria and macrophage activation

Research in Microbiology, 1990
Recent studies that challenged some older concepts have led to the following conclusions: 1) During an infection of mice with M. bovis, BCG macrophages are activated according to certain criteria, but the increase in their bactericidal or bacteriostatic activity is limited to a small number of bacteria species; 2) interferon-gamma can activate ...
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