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Metabolism Supports Macrophage Activation [PDF]

Frontiers in Immunology, 2017
Macrophages are found in most tissues of the body, where they have tissue- and context-dependent roles in maintaining homeostasis as well as coordinating adaptive responses to various stresses.
P Kent Langston
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Activation of macrophages

Comparative Immunology, Microbiology and Infectious Diseases, 1985
The role of macrophages is essential in the development of a normal immune response. Not only are these cells involved in the initiation of this response by presenting antigens to lymphocytes and by producing Interleukin I, but they also participate in the various phenomena of cellular co-operation and regulation.
E, Schneider, M, Dy
openaire   +2 more sources

Activation of macrophages for antimycobacterial activity

Immunology Letters, 1985
The role of macrophage hydrogen peroxide in defense against mycobacterial infection is discussed - not because this is necessarily any more important than other macrophage products (reviews: [1, 2]) but more as a reflection of recently available information.
D B, Lowrie, P S, Jackett, P W, Andrew
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Regulation of macrophage activation

Cellular and Molecular Life Sciences (CMLS), 2003
IFN-gamma rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently undergo a slower classical type 1 activation upon exposure to T helper (Th)1 cytokines such as IFNgamma or other activators, including tumor necrosis factor and lipopolysaccharide, e.g. in intracellular killing of phagocytosed Mycobacterium tuberculosis.
J, Ma, T, Chen, J, Mandelin, A, Ceponis, N E, Miller, M, Hukkanen, G F, Ma, Y T, Konttinen   +7 more
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Macrophage activation revisited

Immunology Today, 1994
Macrophages are extremely adaptable cells, able to modify their behavior in response to diverse signals from other cells and the extracellular matrix. A recent workshop provided insights into current research on these remarkable cells.
A, Celada, C, Nathan
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Polarized Activation of Macrophages

2014
Macrophages are mononuclear phagocytes which play important roles in many aspects of immunity, tissue repair and metabolism. Plasticity is a key feature of these cells and consists in the capability to modulate their phenotypic and functional aspects under distinct stimuli derived from the microenvironment. A number of transcription factors, epigenetic
Galdiero, M. R., Biswas, S. K., Mantovani, A.   +2 more
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Activation of macrophages by neuropeptides

Brain, Behavior, and Immunity, 1988
Macrophages play a key role in the initiation and execution of immunoinflammatory responses. Evidence is reviewed which indicates that neuropeptides are capable of up- or down-regulating their state of activation. Substance P, neurokinin A, neurotensin, bombesin, gastrin-releasing peptide, endorphins, enkephalins, somatotropin, and somatostatin elicit ...
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Macrophage activation syndrome

Current Opinion in Rheumatology, 2002
Macrophage activation syndrome (MAS) is a serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T lymphocytes and macrophages. Recent findings in hemophagocytic lymphohistiocytosis, a disease that is clinically similar to MAS, highlight the possible pathogenetic role ...
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Macrophage activation and polarization

Frontiers in Bioscience, 2008
Macrophages are widely distributed immune system cells that play an indispensable role in homeostasis and defense. They can be phenotypically polarized by the microenvironment to mount specific functional programs. Polarized macrophages can be broadly classified in two main groups: classically activated macrophages (or M1), whose prototypical ...
Martinez FO, SICA, Antonio, Mantovani A, Locati M.   +3 more
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