Results 271 to 280 of about 4,994,603 (399)

The ZFP36-FTO axis is a key regulator of macrophage activation and a druggable therapeutic target of sepsis. [PDF]

iScience
Sarkar R, Wang L, Du J, Blackshear PJ, Li YC.   +4 more
europepmc   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

The BHMT2/MAT1A/AHSG axis promotes M1 macrophage activation and exacerbates necrotizing enterocolitis. [PDF]

Sci Rep
Yue W, Lu X, Tian W, Zhang F, Nong G, Pan G, Zhang X, Yu G.   +7 more
europepmc   +1 more source

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

Proceedings of the National Academy of Sciences of the United States of America, 2017
Dana M. Hardbower, M. Asim, P. Luis, Kshipra Singh, D. Barry, Chunying Yang, Meredith A. Steeves, John L. Cleveland, C. Schneider, M. Piazuelo, A. Gobert, Keith T. Wilson   +11 more
semanticscholar   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Effect of Sardine and Sprat Thermal Processing on Intestinal Integrity and Macrophage Activation In Vitro. [PDF]

Foods
Doskočil I, Lampová B, Šmíd P, Drozdowska M, Kopeć A.   +4 more
europepmc   +1 more source

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

Science, 2017
C. Minutti, L. Jackson-Jones, B. García-Fojeda, Johanna A. Knipper, T. Sutherland, N. Logan, Emma E. Ringqvist, R. Guillamat-Prats, D. Ferenbach, A. Artigas, C. Stamme, Z. Chroneos, D. Zaiss, C. Casals, J. Allen   +14 more
semanticscholar   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation. [PDF]

Gut Microbes
Huang T, Yang H, Zhang L, Wang X, Chen Y, Dai H, Hashimoto K, Luo Y, Pu Y, Liu Y.   +9 more
europepmc   +1 more source