Results 81 to 90 of about 128,741 (174)

Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases

Infection and Drug Resistance, 2019
Jorge Rodrigues de Sousa,1,2 Pedro Fernando Da Costa Vasconcelos,2,3 Juarez Antonio Simões Quaresma1–41Tropical Medicine Center, Federal University of Pará, Belém, PA, Brazil; 2Evandro Chagas Institute, Ministry of Health ...
de Sousa JR, Da Costa Vasconcelos PF, Quaresma JAS   +2 more
doaj  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling

JHEP Reports, 2023
Background & Aims: Oxidative stress-mediated ferroptosis and macrophage-related inflammation play an important role in various liver diseases. Here, we explored if and how hepatocyte ferroptosis regulates macrophage stimulator of interferon genes ...
Wantong Su, Weicheng Gao, Rui Zhang, Qi Wang, Lei Li, Qingfa Bu, Zibo Xu, Zheng Liu, Mingming Wang, Yaqing Zhu, Guoping Wu, Haoming Zhou, Xun Wang, Ling Lu   +13 more
doaj  

Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis

Frontiers in Immunology, 2017
Suppressor of cytokine signaling 3 (SOCS3) is a feedback inhibitor of interleukin (IL)-6 signaling in macrophages. In the absence of this molecule, macrophages become extremely prone to an IL-6-dependent expression of arginase-1 (Arg1) and nitric oxide ...
Erik Schmok, Mahin Abad Dar, Jochen Behrends, Hanna Erdmann, Dominik Rückerl, Tanja Endermann, Lisa Heitmann, Manuela Hessmann, Akihiko Yoshimura, Stefan Rose-John, Stefan Rose-John, Jürgen Scheller, Ulrich Emil Schaible, Stefan Ehlers, Stefan Ehlers, Stefan Ehlers, Roland Lang, Christoph Hölscher, Christoph Hölscher   +18 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Hepatocyte mitochondrial DNA mediates macrophage immune response in liver injury induced by trichloroethylene

Ecotoxicology and Environmental Safety
We have previously shown that excessive activation of macrophage proinflammatory activity plays a key role in TCE-induced immune liver injury, but the mechanism of polarization is unclear. Recent studies have shown that TLR9 activation plays an important
Lei Gao, Xu-Lei Zuo, Luo-Lun Dong, Si-Fan Zhou, Zhou-Jian Wang, Yuan-Sheng Duan, Mu-Yue Chen, Qi-Xing Zhu, Jia-Xiang Zhang   +8 more
doaj  

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

eLife, 2016
Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activation ...
Anthony J Covarrubias, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, Issam Ben-Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul, Erika C Espinosa, Dudley Lamming, Brendan D Manning, Yijing Zhang, Ian A Blair, Tiffany Horng   +15 more
doaj   +1 more source

Modelling of immune cells as vectors of HIV spread inside a patient human body [PDF]

arXiv, 2016
The search to understand how the HIV virus spreads inside the human body and how the immune response works to control it has motivated studies related to Mathematical Immunology. Actually, researches include the idea of mathematical models representing the dynamics of healthy and infected cell populations and focusing on mechanisms used by HIV to ...
arxiv  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Shuyi, A Name After Dendritic Cell-mediated Immunological Memory [PDF]

arXiv, 2019
Immunological memory is a fundamental theory of modern immunology, which is traditionally believed to be mediated only by B and T lymphocytes that recognize antigen epitopes in a receptor-restricted manner. During the last decade data accumulated to show that monocytes and macrophages, the two main initiators of innate immune response, also built up a "
arxiv