Results 81 to 90 of about 641,749 (286)

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]

, 2015
Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay, Habtezion, Aida, Hsieh, Michael H, Murali, Ramachandran, Pandol, Stephen J, Sharma, Vishal, Xue, Jing   +6 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation

Scientific Reports, 2021
Spinal cord injury (SCI) produces chronic, pro-inflammatory macrophage activation that impairs recovery. The mechanisms driving this chronic inflammation are not well understood.
Timothy J. Kopper, Bei Zhang, William M. Bailey, Kara E. Bethel, John C. Gensel   +4 more
doaj   +1 more source

Vomocytosis: Too Much Booze, Base, or Calcium? [PDF]

, 2019
Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules.
Aaron, Alvarez, Alvarez, Artavanis-Tsakonas, Bain, Ben-Abdallah, Bielska, Blackstock, Boya, Bryan, Burch, Chang, Charlier, Chen, Cheng, Chu, Circu, Cox, Davis, De Leon-Rodriguez, De Leon-Rodriguez, Denham, Di, Diamond, Doshi, Dragotakes, Drew, Erb-Downward, Erwig, Evans, Feldmesser, Franchi, Fu, Gilbert, Gordon, Guerra, Gustafson, Haka, Han, Henson, Heo, Hibbs, Hoag, Hommel, Huang, Hybiske, Iwasaki, Johnston, Kjos, Kleinschek, Kruskal, Kusner, Lei, Leopold Wager, Levitz, Levitz, Lim, Liu, Lévêque, Ma, Maderna, May, Milam, Mosser, Murdock, Murray, Myers, Müller, Nel, Nicola, Nunes, Okagaki, O’Meara, Pauwels, Qiu, Rajasingham, Russell, Samantaray, Santiago-Tirado, Singh, Smith, Stukes, Stukes, Swisher, Tucker, Vashi, Voelz, Vu, Vu, Walkey, Wang, Wang, Watkins, Weiss, Wormley, Wozniak, Yates, Yoshida, Zaragoza   +98 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Macrophage WDFY3 mitigates autoimmunity by enhancing efferocytosis and suppressing T cell activation in mice

Nature Communications
Efficient efferocytosis is crucial for immune homeostasis. Conversely, excessive apoptotic cell (AC) death and impaired macrophage efferocytosis lead to autoantigen release, autoantibody production, and immune activation.
Xun Wu, Ziyi Wang, Katherine R. Croce, Fang Li, Jian Cui, Vivette D. D’Agati, Rajesh K. Soni, Ira Tabas, Ai Yamamoto, Hanrui Zhang   +9 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Treating Macrophages with Anti-inflammatory Nanoparticles as a Strategy to Improve Muscle Repair [PDF]

, 2019
The macrophage is an immune cell that is involved in host defense. More recent research, however, has revealed that they also play a central role in mediating the skeletal muscle regenerative process.
Yan, Derek
core   +1 more source

Alveolar Macrophage Plasminogen Activator

Experimental Lung Research, 1984
Plasminogen activator is a neutral serine protease secreted by many different cells, including activated peritoneal macrophages, which can mediate both inflammation and fibrinolysis and perhaps cytolysis of tumor cells. Secretion of plasminogen activator by rabbit alveolar macrophages derived from normal animals and rabbits pretreated with bacillus ...
M, Schuyler, W, Forman
openaire   +2 more sources