Results 81 to 90 of about 4,994,603 (399)

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Cell Metabolism, 2019
Summary How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A).
Daniel J. Puleston, Daniel J. Puleston, Michael D. Buck, R. K. Geltink, Ryan L. Kyle, G. Caputa, David O’Sullivan, Alanna M. Cameron, Angela Castoldi, Y. Musa, A. Kabat, Ying Zhang, Lea J. Flachsmann, Cameron S. Field, Annette E. Patterson, S. Scherer, Francesca Alfei, Francesc Baixauli, S. Austin, B. Kelly, M. Matsushita, Jonathan D. Curtis, Katarzyna M. Grzes, M. Villa, M. Corrado, David E Sanin, J. Qiu, Nora Pällman, Katelyn Paz, M. Maccari, B. Blazar, Gerhard Mittler, Joerg M. Buescher, D. Zehn, S. Rospert, Edward J. Pearce, Edward J. Pearce, S. Balabanov, Erika L. Pearce   +38 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]

, 2010
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M., Hamann, Jörg, Hoek, Robert M., Huitinga, Inge, Koning, Nathalie, Pouwels, Walter, Raes, Geert, van Eijk, Marco, Voehringer, David   +8 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Integrated immunogenomic analysis of single-cell and bulk tissue transcriptome profiling unravels a macrophage activation paradigm associated with immunologically and clinically distinct behaviors in ovarian cancer

Journal of Advanced Research, 2023
Introduction: Increasing evidence demonstrates that the activation states and diverse spectrum of macrophage subtypes display dynamic heterogeneity in the tumor microenvironment, which plays a critical role in a variety of cancer types.
Congcong Yan, Ke Li, Fanling Meng, Lu Chen, Jingting Zhao, Zicheng Zhang, Dandan Xu, Jie Sun, Meng Zhou   +8 more
doaj   +1 more source

LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE

Science Advances, 2019
PTPRE-AS1 deficiency aggravates pulmonary inflammation but reduces colitis severity by modulating M2 macrophage activation. Long noncoding RNAs (lncRNAs) are important regulators of diverse biological processes; however, their function in macrophage ...
Xiao Han, Saihua Huang, P. Xue, Jinrong Fu, Lijuan Liu, Caiyan Zhang, Lan Yang, Li Xia, Licheng Sun, Shau-ku Huang, Yufeng Zhou   +10 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Interleukin-4 ameliorates the functional recovery of intracerebral hemorrhage through the alternative activation of microglia/macrophage

Frontiers in Neuroscience, 2016
Neuro-inflammation plays an important role in the recovery of brain injury after stroke. Microglia/macrophage is the major executor in the neuro-inflammation, which can be polarized into two distinct phenotypes: injurious/toxic classical activation (M1 ...
Jianjing eYang, Saidan eDing, Weilong eHuang, Yu eZhang, Zhuge eQichuan, Zhuge eQichuan   +5 more
doaj   +1 more source

Vomocytosis: Too Much Booze, Base, or Calcium? [PDF]

, 2019
Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules.
Aaron, Alvarez, Alvarez, Artavanis-Tsakonas, Bain, Ben-Abdallah, Bielska, Blackstock, Boya, Bryan, Burch, Chang, Charlier, Chen, Cheng, Chu, Circu, Cox, Davis, De Leon-Rodriguez, De Leon-Rodriguez, Denham, Di, Diamond, Doshi, Dragotakes, Drew, Erb-Downward, Erwig, Evans, Feldmesser, Franchi, Fu, Gilbert, Gordon, Guerra, Gustafson, Haka, Han, Henson, Heo, Hibbs, Hoag, Hommel, Huang, Hybiske, Iwasaki, Johnston, Kjos, Kleinschek, Kruskal, Kusner, Lei, Leopold Wager, Levitz, Levitz, Lim, Liu, Lévêque, Ma, Maderna, May, Milam, Mosser, Murdock, Murray, Myers, Müller, Nel, Nicola, Nunes, Okagaki, O’Meara, Pauwels, Qiu, Rajasingham, Russell, Samantaray, Santiago-Tirado, Singh, Smith, Stukes, Stukes, Swisher, Tucker, Vashi, Voelz, Vu, Vu, Walkey, Wang, Wang, Watkins, Weiss, Wormley, Wozniak, Yates, Yoshida, Zaragoza   +98 more
core   +2 more sources

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

Annals of the Rheumatic Diseases, 2016
To develop criteria for the classification of macrophage activation syndrome (MAS) in patients with systemic juvenile idiopathic arthritis (JIA). A multistep process, based on a combination of expert consensus and analysis of real patient data, was ...
A. Ravelli, F. Minoia, S. Davì, A. Horne, F. Bovis, A. Pistorio, M. Aricò, T. Avčin, Edward M. Behrens, F. De Benedetti, L. Filipovic, A. Grom, J. Henter, Norman T. Ilowite, Michael B. Jordan, R. Khubchandani, T. Kitoh, K. Lehmberg, D. Lovell, P. Miettunen, Kim E Nichols, S. Ozen, J. Pachlopnik Schmid, A. Ramanan, R. Russo, R. Schneider, G. Sterba, Y. Uziel, C. Wallace, C. Wouters, N. Wulffraat, E. Demirkaya, H. Brunner, A. Martini, N. Ruperto, R. Cron   +35 more
semanticscholar   +1 more source