Efficacy and safety of emapalumab in macrophage activation syndrome. [PDF]
Ann Rheum Dis, 2023 ABSTRACTObjectivesMacrophage activation syndrome (MAS) is a severe, life-threatening complication of systemic juvenile idiopathic arthritis (sJIA) and adult onset Still’s disease (AOSD). The objective of this study was to confirm the adequacy of an emapalumab dosing regimen in relation to interferon-γ (IFNγ) activity by assessing efficacy and safety ...
De Benedetti F +16 more
europepmc +6 more sources
Macrophage activation syndrome: early diagnosis is key [PDF]
Open Access Rheumatology: Research and Reviews, 2018 Butsabong Lerkvaleekul, Soamarat Vilaiyuk Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Abstract: Macrophage activation syndrome (MAS) is a life-threatening condition ...
Lerkvaleekul B, Vilaiyuk S
doaj +4 more sources
mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
Nature Communications, 2022 Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome.
Zhengping Huang +30 more
doaj +2 more sources
Macrophage Activation Syndrome in Children: Diagnosis and Management [PDF]
Indian Pediatrics, 2021 Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality.
Bagri, Narendra Kumar +3 more
openaire +3 more sources
Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19 [PDF]
Scientific Reports, 2021 Hyperactivation of the immune system through obesity and diabetes may enhance infection severity complicated by Acute Respiratory Distress Syndrome (ARDS).
Abu Saleh Md Moin +4 more
doaj +2 more sources
Macrophage Activation Syndrome as a Complication of Systemic Lupus Erythematosus in an Adult Male [PDF]
Marshall Journal of Medicine, 2020 Macrophage activation syndrome (MAS) is a rare life-threatening complication that sometimes occurs in patients with systemic lupus erythematosus (SLE) and other connective tissue diseases.
Rajesh Gopalarathinam +2 more
doaj +2 more sources
Macrophage activation syndrome in systemic juvenile idiopathic arthritis
Immunological Medicine, 2021 Macrophage activation syndrome (MAS) is a severe, potentially life-threatening complication of systemic juvenile idiopathic arthritis (s-JIA). An immunological feature is the excessive activation and proliferation of T lymphocytes and macrophages ...
Masaki Shimizu
doaj +2 more sources
Macrophage activation syndrome: A diagnostic challenge (Review)
Experimental and Therapeutic Medicine, 2021 Macrophage activation syndrome (MAS) represents an acute and severe inflammatory syndrome, idiopathic (primary) or secondary to infections, rheumatic diseases, malignancies, or drugs. MAS is underdiagnosed, being confused with sepsis, adverse effects of anti-arthritic drugs or exacerbated symptoms of evolving rheumatologic or infectious diseases ...
Iulia-Andrea Zsoldos +4 more
openaire +5 more sources
Histiocytic glomerulopathy associated with macrophage activation syndrome [PDF]
Clinical Kidney Journal, 2015 We present an interesting case of a 37-year old man with acute renal failure following a febrile illness. Laboratory results showed features of macrophage activation syndrome (MAS) with anemia, thrombocytopenia, hypofibrinogenemia and elevated ferritin levels.
Alfonso Eirin +3 more
openalex +4 more sources
Macrophage activation syndrome, a rare complication of primary Sjögren’s syndrome: a case report [PDF]
Journal of Medical Case Reports, 2019 Background The association of macrophage activation syndrome and primary Sjögren’s syndrome has been rarely reported in the literature. We report the first observation of this association in Africa, south of the Sahara, and we discuss the diagnosis and ...
B. S. Kane +10 more
doaj +2 more sources