Results 81 to 90 of about 261,254 (319)

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk. [PDF]

, 2019
Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing ...
Baritaki, Stavroula, Chatzaki, Ekaterini, de Bree, Eelco, Pothoulakis, Charalabos   +3 more
core   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19

Scientific Reports, 2021
Hyperactivation of the immune system through obesity and diabetes may enhance infection severity complicated by Acute Respiratory Distress Syndrome (ARDS).
Abu Saleh Md Moin, Thozhukat Sathyapalan, Ilhame Diboun, Stephen L. Atkin, Alexandra E. Butler   +4 more
doaj   +1 more source

Type I interferon signature and cycling lymphocytes in macrophage activation syndrome [PDF]

, 2023
Zhengping Huang, Kailey Brodeur, Liang Chen, Du, Holly Wobma, Evan E. Hsu, Meng Liu, Joyce C. Chang, Margaret H. Chang, Janet Chou, Megan Day‐Lewis, Fatma Dedeoğlu, Olha Halyabar, James A. Lederer, Li T, Mindy S. Lo, Meiping Lu, Esra Meidan, Jane W. Newburger, Adrienne G. Randolph, Mary Beth F. Son, Robert P. Sundel, Maria L. Taylor, Huaxiang Wu, Qing Zhou, Scott Canna, Kevin Wei, Lauren A. Henderson, Peter A. Nigrović, Pui Y. Lee   +29 more
openalex   +1 more source

Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress [PDF]

, 2008
An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been described. An aging-associated reduction in AMPK activity
Erin Lane, Heng Ma, Ji Li, Jingying Wang, Jun Ren, Lin Leng, Richard Bucala, Wenkui Wang   +7 more
core   +1 more source

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. [PDF]

, 2018
HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination
DeChristopher, Brian A, Hardman, Clayton T, Ho, Stephen, Loy, Brian A, Marsden, Matthew D, Navab, Sara M, Ramirez, Christina M, Schrier, Adam J, Shimizu, Akira J, Wender, Paul A, Wu, Xiaomeng, Zack, Jerome A   +11 more
core   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Macrophage activation syndrome with acute hepatitis in a patient with adult-onset immunodeficiency with anti-interferon gamma antibodies: a case report

Journal of Medical Case Reports
Background Macrophage activation syndrome is a rare disorder leading to unregulated immune activity manifesting with nonspecific constitutional symptoms, laboratory abnormalities, and multiorgan involvement.
William Hirsch, Bryant Megna, Oyedele Adeyi, Nicholas Lim   +3 more
doaj   +1 more source

Clinical features and treatment outcomes of pediatric Langerhans cell histiocytosis with macrophage activation syndrome-hemophagocytic lymphohistiocytosis [PDF]

, 2022
Dong Wang, Xihua Chen, Ang Wei, Chunju Zhou, Xue Zhang, Honghao Ma, Hongyun Lian, Li Zhang, Qing Zhang, Xiao‐Tong Huang, Chanjuan Wang, Ying Yang, Wei Liu, Tianyou Wang, Zhigang Li, Lei Cui, Rui Zhang   +16 more
openalex   +1 more source