Results 51 to 60 of about 1,228,727 (302)

Bioelectric modulation of macrophage polarization [PDF]

Scientific Reports, 2016
AbstractMacrophages play a critical role in regulating wound healing and tissue regeneration by changing their polarization state in response to local microenvironmental stimuli. The native roles of polarized macrophages encompass biomaterials and tissue remodeling needs, yet harnessing or directing the polarization response has been largely absent as ...
David L. Kaplan, Chunmei Li, Michael Levin   +2 more
openaire   +3 more sources

Cholinergic Polarization of Human Macrophages

International Journal of Molecular Sciences, 2023
Macrophages serve as vital defenders, protecting the body by exhibiting remarkable cellular adaptability in response to invading pathogens and various stimuli. These cells express nicotinic acetylcholine receptors, with the α7-nAChR being extensively studied due to its involvement in activating the cholinergic anti-inflammatory pathway.
Natalia Roa-Vidal, Adriana S. Rodríguez-Aponte, José A. Lasalde-Dominicci, Coral M. Capó-Vélez, Manuel Delgado-Vélez   +4 more
openaire   +2 more sources

Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective

Antioxidants, 2022
Macrophage polarization refers to the process by which macrophages can produce two distinct functional phenotypes: M1 or M2. The balance between both strongly affects the progression of inflammatory disorders.
S. Pérez, Sergio Rius-Pérez
semanticscholar   +1 more source

Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. [PDF]

, 2016
In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates
Barton, Elisabeth R, Capote, Joana, Kramerova, Irina, Martinez, Leonel, Miceli, M Carrie, Spencer, Melissa J, Sweeney, H Lee, Vetrone, Sylvia   +7 more
core   +2 more sources

Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Critical Care, 2021
Polymorphonuclear neutrophils (PMNs) play an important role in sepsis-related acute lung injury (ALI). Accumulating evidence suggests PMN-derived exosomes as a new subcellular entity acting as a fundamental link between PMN-driven inflammation and tissue
Yang Jiao, Ti Zhang, Chengmi Zhang, Haiying Ji, Xingyu Tong, Ran Xia, Wei Wang, Zhengliang Ma, Xueyin Shi   +8 more
semanticscholar   +1 more source

Transcriptional profiling identifies novel regulators of macrophage polarization.

PLoS ONE, 2018
Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. Major advances have occurred in understanding the transcriptional, epigenetic, and functional differences in various ...
Kimberline Y Gerrick, Elias R Gerrick, Anuj Gupta, Sarah J Wheelan, Srinivasan Yegnasubramanian, Elizabeth M Jaffee   +5 more
doaj   +1 more source

Polarization and Repolarization of Macrophages

Journal of Clinical and Cellular Immunology, 2015
Macrophages can acquire distinct phenotypes and biological functions depending on the microenvironment and the metabolic state. Macrophages classically activated by IFN-γ and/or microbial products display an M1 phenotype characterized by high expression of interleukin (IL)-12, inducible nitric oxide synthase (iNOS) and TNF-α.
FRATERNALE, ALESSANDRA, BRUNDU, SERENA, MAGNANI, MAURO   +2 more
openaire   +3 more sources

CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype

Journal for ImmunoTherapy of Cancer, 2022
Background Platinum resistance is a major challenge in the clinical treatment of advanced ovarian cancer (OC). Accumulating evidence shows that the tumor-promotive M2 macrophage is linked to the limiting chemotherapy efficacy of multiple malignancies ...
Han Li, Fan Luo, Xing-jin Jiang, Weijing Zhang, T. Xiang, Q. Pan, Liming Cai, Jing‐jing Zhao, D. Weng, Yue Li, Yuhu Dai, Fengze Sun, Chaopin Yang, Yue Huang, Jieying Yang, Yan Tang, Yulong Han, M. He, Yanna Zhang, Libing Song, J. Xia   +20 more
semanticscholar   +1 more source

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. [PDF]

, 2018
Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in glioblastoma (GBM).
Brem, Steven, Dahmane, Nadia, Duan, Hao, Fan, Yi, Gong, Yanqing, He, Zhenqiang, Hidalgo, Juan, Huang, Menggui, Liu, Tianrun, Ma, Peihong, Mou, Yonggao, O'Rourke, Donald M, Wang, Qirui, Wang, Yanling, Xu, Haineng, Zamvil, Scott S, Zhang, Lin, Zhang, Zhenfeng   +17 more
core   +3 more sources

Macrophage M1 polarization mediated via the IL-6/STAT3 pathway contributes to apical periodontitis induced by Porphyromonas gingivalis [PDF]

, 2022
Objective: To investigate the involvement of IL-6/STAT3 signaling pathway activation in macrophage polarization and bone destruction related to apical periodontitis (AP) stimulated by Porphyromonas gingivalis.
Chen, Xuan, Dou, Jinge, Fu, Zhuohui, Huang, Dingming, Qiu, Yang, Tan, Xuelian, Zou, Ling   +6 more
core   +2 more sources