Results 121 to 130 of about 261,309 (244)

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

Image_1_Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis.jpeg

IntroductionOsteoarthritis (OA) is a prevalent joint disorder characterized by multifaceted pathogenesis, with macrophage dysregulation playing a critical role in perpetuating inflammation and joint degeneration.
Chun-Long Hu (17953883), Xi-Xi He (3202416), Qiong-Qian Xu (17953886), Yuan-Jun Huang (17953880), Qing-Jun Wei (11496527)   +4 more
core   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Image_3_Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis.jpeg

IntroductionOsteoarthritis (OA) is a prevalent joint disorder characterized by multifaceted pathogenesis, with macrophage dysregulation playing a critical role in perpetuating inflammation and joint degeneration.
Chun-Long Hu (17953883), Xi-Xi He (3202416), Qiong-Qian Xu (17953886), Yuan-Jun Huang (17953880), Qing-Jun Wei (11496527)   +4 more
core   +1 more source

Oligonucleotide‐Based Modulation of Macrophage Polarization: Emerging Strategies in Immunotherapy

Immunity, Inflammation and Disease
Background Recent advances in immunotherapy have spotlighted macrophages as central mediators of disease treatment. Their polarization into pro‑inflammatory (M1) or anti‑inflammatory (M2) states critically influences outcomes in cancer, autoimmunity, and
Hanfu Zhang, Yizhi Yu, Cheng Qian
doaj   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Image_6_Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis.jpeg

IntroductionOsteoarthritis (OA) is a prevalent joint disorder characterized by multifaceted pathogenesis, with macrophage dysregulation playing a critical role in perpetuating inflammation and joint degeneration.
Chun-Long Hu (17953883), Xi-Xi He (3202416), Qiong-Qian Xu (17953886), Yuan-Jun Huang (17953880), Qing-Jun Wei (11496527)   +4 more
core   +1 more source