Results 1 to 10 of about 1,368,417 (273)
Frontiers in Physiology, 2018 Macrophages play key roles in all phases of adult wound healing, which are inflammation, proliferation, and remodeling. As wounds heal, the local macrophage population transitions from predominantly pro-inflammatory (M1-like phenotypes) to anti ...
Paulina Krzyszczyk +3 more
semanticscholar +3 more sources
Distinct Responses to IL4 in Macrophages Mediated by JNK
Cells, 2023 IL(Interleukin)-4 is the main macrophage M2-type activator and induces an anti-inflammatory phenotype called alternative activation. The IL-4 signaling pathway involves the activation of STAT (Signal Transducer and Activator of Transcription)-6 and ...
Luís Arpa +5 more
doaj +1 more source
GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation
Cells, 2022 At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation
Tania Vico +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2022 Immunological memory is a crucial part of the immune defense that allows organisms to respond against previously encountered pathogens or other harmful factors. Immunological memory is based on the establishment of epigenetic modifications of the genome.
Malgorzata Kloc +3 more
openaire +2 more sources
Macrophages in immunoregulation and therapeutics
Signal Transduction and Targeted Therapy, 2023 Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.
Shanze Chen +7 more
semanticscholar +1 more source
eLife, 2022 Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms.
Clarisse Leseigneur +6 more
doaj +1 more source
In silico prediction of protein-protein interactions in human macrophages [PDF]
BMC Research Notes, 2001 Protein-protein interaction (PPI) network analyses are highly valuable in deciphering and understanding the intricate organisation of cellular functions.
Oussema Souiai +4 more
semanticscholar +1 more source
Macrophages as tools and targets in cancer therapy
Nature reviews. Drug discovery, 2022 Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix remodelling, cancer cell proliferation, metastasis and immunosuppression, as well as in ...
A. Mantovani +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Matrix stiffness, a critical physical property of the cellular environment, is implicated in epidermal homeostasis. In particular, matrix stiffening during the pathological progression of skin diseases appears to contribute to cellular responses of ...
Hyewon Chung +8 more
doaj +1 more source
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
Nature reviews. Immunology, 2020 The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in ...
M. Merad, Jérôme C. Martin
semanticscholar +1 more source