Results 1 to 10 of about 1,971,731 (404)
Macrophages as tools and targets in cancer therapy
Nature Reviews Drug Discovery, 2022 Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix remodelling, cancer cell proliferation, metastasis and immunosuppression, as well as in ...
Alberto Mantovani +2 more
exaly +2 more sources
Tumor-Associated Macrophages in Tumor Immunity
Frontiers in Immunology, 2020 Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated ...
Xiaojian Wang, Ting Zhang, Hanno Steen
exaly +2 more sources
Tumor-Associated Macrophages: Recent Insights and Therapies
Frontiers in Oncology, 2020 Macrophages, which have functions of engulfing and digesting foreign substances, can clear away harmful matter, including cellular debris and tumor cells.
Ziwei Tang, R M Bianchi, Xikun Zhou
exaly +2 more sources
Macrophages as regulators of tumour immunity and immunotherapy
Nature Reviews Immunology, 2019 David G Denardo, Brian Ruffell
exaly +2 more sources
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
Nature, 2021 Brian D Brown +2 more
exaly +2 more sources
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
Nature, 2014 Oscar Colegio, Vikram Jairam, Nika Cyrus
exaly +2 more sources
Distinct Responses to IL4 in Macrophages Mediated by JNK
Cells, 2023 IL(Interleukin)-4 is the main macrophage M2-type activator and induces an anti-inflammatory phenotype called alternative activation. The IL-4 signaling pathway involves the activation of STAT (Signal Transducer and Activator of Transcription)-6 and ...
Luís Arpa +5 more
doaj +1 more source
GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation
Cells, 2022 At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation
Tania Vico +6 more
doaj +1 more source
Macrophages in immunoregulation and therapeutics
Signal Transduction and Targeted Therapy, 2023 Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.
Shanze Chen +7 more
semanticscholar +1 more source
Tissue-specific macrophages: how they develop and choreograph tissue biology
Nature reviews. Immunology, 2023 Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying cells and cell debris, immune complexes, bacteria and other waste products. Simultaneously, they produce growth factors and signalling molecules —
E. Mass +3 more
semanticscholar +1 more source