Results 51 to 60 of about 183,665 (310)

Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury

Respiratory Research, 2005
Background Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate ...
Reyes Livia, Pasch Thomas, Schwendener Reto, Beck-Schimmer Beatrice, Booy Christa, Schimmer Ralph C   +5 more
doaj   +1 more source

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D., Buttini, Francesca, Cavaco, Joana S., Grenha, Ana, Guerreiro, Filipa, Pontes, Jorge Filipe, Rodrigues, Susana, Rosa Da Costa, Ana   +7 more
core   +1 more source

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

Targeting murine alveolar macrophages by the intratracheal administration of locked nucleic acid containing antisense oligonucleotides

Drug Delivery, 2019
The pulmonary delivery of locked nucleic acid containing antisense oligonucleotides (LNA-ASOs) is expected to be a novel therapeutic approach for lung diseases.
Yasunori Uemura, Katsuya Kobayashi
doaj   +1 more source

ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis

Journal of Lipid Research, 2007
Patients with pulmonary alveolar proteinosis (PAP) display impaired surfactant clearance, foamy, lipid-filled alveolar macrophages, and increased cholesterol metabolites within the lung.
Mary Jane Thomassen, Barbara P. Barna, Achut G. Malur, Tracey L. Bonfield, Carol F. Farver, Anagha Malur, Heidi Dalrymple, Mani S. Kavuru, Maria Febbraio   +8 more
doaj   +1 more source

Microvesicle-Mediated Communication Within the Alveolar Space: Mechanisms of Uptake by Epithelial Cells and Alveolar Macrophages

Frontiers in Immunology, 2022
Intra-alveolar microvesicles (MVs) are important mediators of inter-cellular communication within the alveolar space, and are key components in the pathophysiology of lung inflammation such as acute respiratory distress syndrome (ARDS).
Sanooj Soni, Kieran P. O’Dea, Eiko Abe, Maryam Khamdan, Sneh V. Shah, Padmini Sarathchandra, Michael R. Wilson, Masao Takata   +7 more
doaj   +1 more source

Hydrogen peroxide release by OKI A1 (anti DR-Monoclonal antibody) resustabt alveolar mnacrophages in tuberculosis [PDF]

, 1989
Phorbol myristate acetate (PMA) triggered hydrogen peroxide (H2O2) release from alveolar macrophages and corresponding blood monocytes were studied as a whole, in active tuberculosis, inactive tuberculosis (treated), non-tuberculous lung disease ...
Narayanan, P R, Prabhakar, R, Raji, Swamy, Selvaraj, P, Vijayan, V K   +4 more
core  

Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism [PDF]

, 2001
Pulmonary surfactant is a multimolecular complex located at the air-water interface within the alveolus to which a range of physical (surface-active properties) and immune functions has been assigned. This complex consists of a surface-active lipid layer
Clements JA, Crouch E, deMello DE, Dirksen U, Doyle IR, Fisher JH, Floros J, Glasser SW, Green D, Hawgood S, Ikegami M, Ikegami M, Ikegami M, Kitamura T, Kresch MJ, Madan T, Mahut B, Mason RJ, Myrianthopoulos NC, Nogee LM, Pilot-Matias TJ, Power JHT, Prakash UBS, Reed JA, Robertson B, Rosen SH, Stoll BJ, Tredano M, Vorbroker DK, Wang J-Y   +29 more
core   +1 more source

Sensorized Engineered Tissues with Built‐in Thermoregulation and Nutrient Supply

Advanced Functional Materials, EarlyView.
This work introduces a granular hydrogel‐based tissue engineering platform that includes a closed‐loop temperature control to maintain 37°C and sustainably releases nutrients, thereby enabling cells to retain a high viability even if stored at room temperature for up to 24 h.
Antonia Georgopoulou, Jakob Schreiner, Miriam Filippi, Aiste Balciunaite, Robert K. Katzschmann, Esther Amstad   +5 more
wiley   +1 more source

Stimulation of cyclic AMP production in human alveolar macrophages induced by inflammatory mediators and β-sympathicomimetics [PDF]

, 1992
We have investigated the effects of inflammatory mediators and β-adrenoceptor agonists on the adenylyl cyclase responsiveness in alveolar macrophages from control subjects, patients suffering from chronic obstructive pulmonary disease (COPD) and ...
Amsterdam, J.G.C. (Jan) van, Beusenberg, F.D., Bonta, I.L., Brouwers, J.W., Hekking, P.R.M. (P. R M), Hoogsteden, H.C. (Henk), Schermers, H.P. (H.)   +6 more
core   +1 more source