Results 21 to 30 of about 2,020,072 (390)

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder

Frontiers in Cellular and Infection Microbiology, 2022
Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other therapeutic or prophylactic interventions.
Valerio Laghi, Veronica Rezelj, Laurent Boucontet, Maxence Frétaud, Bruno Da Costa, Pierre Boudinot, Irene Salinas, Georges Lutfalla, Marco Vignuzzi, Jean-Pierre Levraud, Jean-Pierre Levraud   +10 more
doaj   +1 more source

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Nature reviews. Immunology, 2020
The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in ...
M. Merad, Jérôme C. Martin
semanticscholar   +1 more source

Tissue-specific macrophages: how they develop and choreograph tissue biology

Nature reviews. Immunology, 2023
Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying cells and cell debris, immune complexes, bacteria and other waste products. Simultaneously, they produce growth factors and signalling molecules —
E. Mass, F. Nimmerjahn, Katrin Kierdorf, A. Schlitzer   +3 more
semanticscholar   +1 more source

The complex TIE between macrophages and angiogenesis [PDF]

, 2020
Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration.
Anghelina M., Avraham‐Davidi I., Baer C., Bailey A. S., Barnett F. H., Bonnardel J., Chakarov S., Chen L., Coffelt S. B., Corliss B. A., Cursiefen C., Daly C., Davies L. C., Davies L. C., De Palma M., De Palma M., De Palma M., De Palma M., De Palma M., De Spiegelaere W., DeFalco T., Deshmane S. L., Detry B., Dimova I., Dimova I., Eklund L., Elamaa H., Eubank T. D., Fantin A., Ferrari G., Fukuhara S., Ganta V. C., Ganta V. C., García S., Gerri C., Grunewald M., Guo L., Gurevich D. B., Hamm A., Hazan A. D., He H., Hoeffel G., Itoh M., Jetten N., Kim M., Kochhan E., Korhonen E. A., Korpelainen E. I., Krishnasamy K., Kumar A. H., Leibovich S. J., Lim H. Y., Liu C., Lucas T., Master Z., Metharom P., Michaeli S., Moldovan N. I., Moore E. M., Mueller S. B., Murdoch C., Murray P. J., Patel A. S., Polverini P. J., Potente M., Pucci F., Saharinen P., Saharinen P., Schif‐Zuck S., Schmeisser A., Seaman S. A., Seok S. H., Spiller K. L., Venneri M. A., Vestweber D., Webster N. L., West M. E. D., Willenborg S., Yamamoto S., Zajac E., Zenker D., Zhang W.   +81 more
core   +2 more sources

A User-Friendly Approach for Routine Histopathological and Morphometric Analysis of Skeletal Muscle Using CellProfiler Software

Diagnostics, 2022
Adult skeletal muscle is capable of active and efficient differentiation in the event of injury in both physiological and pathological conditions, such as in Duchenne muscular dystrophy (DMD).
Valerio Laghi, Valentina Ricci, Francesca De Santa, Alessio Torcinaro   +3 more
doaj   +1 more source

Age-related changes to macrophages are detrimental to fracture healing in mice. [PDF]

, 2020
The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age ...
Brazina, Sloane, Clark, Daniel, Hsieh, Christine L, Hu, Diane, Marcucio, Ralph, Miclau, Theodore, Nakamura, Mary C, Niemi, Erene C, Yang, Frank   +8 more
core   +2 more sources

The Macrophage Paradox [PDF]

Immunity, 2014
Macrophages are a diverse population of phagocytic cells that reside in tissues throughout the body. At sites of infection, macrophages encounter and engulf invading microbes. Accordingly, macrophages possess specialized effector functions to kill or coordinate the elimination of their prey.
Jordan V. Price, Russell E. Vance
openaire   +3 more sources

Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

eLife, 2023
The regulation of inflammatory responses is an important intervention in biological function and macrophages play an essential role during inflammation.
Atomu Yamaguchi, Noriaki Maeshige, Hikari Noguchi, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Dongming Su, Hiroyo Kondo, Kristopher Sarosiek, Hidemi Fujino   +9 more
doaj   +1 more source

PTEN inhibits AMPK to control collective migration

Nature Communications, 2022
Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.
Florent Peglion, Lavinia Capuana, Isabelle Perfettini, Laurent Boucontet, Ben Braithwaite, Emma Colucci-Guyon, Emie Quissac, Karin Forsberg-Nilsson, Flora Llense, Sandrine Etienne-Manneville   +9 more
doaj   +1 more source

Anti-PD-1 therapy activates tumoricidic properties of NKT cells and contributes to the overall deceleration of tumor progression in a model of murine mammary carcinoma [PDF]

Vojnosanitetski Pregled, 2022
Background/Aim. Immune checkpoint therapy is a well-established therapeutic approach in the treatment of malignant diseases and is thought to be mostly based on facilitating the adaptive immune response.
Jovanović Marina, Gajović Nevena, Jurišević Milena, Sekulić Sofija, Arsenijević Nebojša, Jocić Miodrag, Jovanović Milan, Lukić Ružica, Jovanović Ivan, Radovanović Dragče   +9 more
doaj   +1 more source