Results 21 to 30 of about 1,971,731 (404)

Age-related changes to macrophages are detrimental to fracture healing in mice. [PDF]

, 2020
The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age ...
Brazina, Sloane, Clark, Daniel, Hsieh, Christine L, Hu, Diane, Marcucio, Ralph, Miclau, Theodore, Nakamura, Mary C, Niemi, Erene C, Yang, Frank   +8 more
core   +2 more sources

GSK-3α/β Activity Negatively Regulates MMP-1/9 Expression to Suppress Mycobacterium tuberculosis Infection

Frontiers in Immunology, 2022
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is the deadliest infectious disease and a global health problem. Macrophages (Mφs) and neutrophils that can phagocytose Mtb represent the first line of immune response to infection ...
Xinying Zhou, Linmiao Lie, Yao Liang, Hui Xu, Bo Zhu, Yingqi Huang, Lijie Zhang, Zelin Zhang, Qianna Li, Qi Wang, Zhenyu Han, Yulan Huang, Honglin Liu, Shengfeng Hu, Chaoying Zhou, Qian Wen, Li Ma   +16 more
doaj   +1 more source

PTEN inhibits AMPK to control collective migration

Nature Communications, 2022
Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.
Florent Peglion, Lavinia Capuana, Isabelle Perfettini, Laurent Boucontet, Ben Braithwaite, Emma Colucci-Guyon, Emie Quissac, Karin Forsberg-Nilsson, Flora Llense, Sandrine Etienne-Manneville   +9 more
doaj   +1 more source

Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy

Microbiology Spectrum, 2021
The therapeutic repertoire for tuberculosis (TB) remains limited despite the existence of many TB drugs that are highly active in in vitro models and possess clinical utility.
Lloyd Tanner, Gabriel T. Mashabela, Charles C. Omollo, Timothy J. de Wet, Christopher J. Parkinson, Digby F. Warner, Richard K. Haynes, Lubbe Wiesner   +7 more
doaj   +1 more source

Pro-Resolving Factors Released by Macrophages After Efferocytosis Promote Mucosal Wound Healing in Inflammatory Bowel Disease

Frontiers in Immunology, 2021
Nonresolving inflammation is a critical driver of several chronic inflammatory diseases, including inflammatory bowel diseases (IBD). This unresolved inflammation may result from the persistence of an initiating stimulus or from the alteration of the ...
Omayra Martin-Rodriguez, Thierry Gauthier, Francis Bonnefoy, Francis Bonnefoy, Mélanie Couturier, Mélanie Couturier, Anna Daoui, Cécile Chagué, Séverine Valmary-Degano, Claire Gay, Philippe Saas, Sylvain Perruche, Sylvain Perruche   +12 more
doaj   +1 more source

Memory Macrophages

International Journal of Molecular Sciences, 2022
Immunological memory is a crucial part of the immune defense that allows organisms to respond against previously encountered pathogens or other harmful factors. Immunological memory is based on the establishment of epigenetic modifications of the genome.
Malgorzata Kloc, Jacek Z. Kubiak, Robert Zdanowski, Rafik M. Ghobrial   +3 more
openaire   +2 more sources

Tissue-Resident Macrophages in the Stria Vascularis

Frontiers in Neurology, 2022
Tissue-resident macrophages play an important role in clearance, development, and regulation of metabolism. They also function as sentinel immune cells, initiating inflammatory responses, clearing inflammatory debris, and maintaining homeostatic tissue ...
Taku Ito, Natsuko Kurata, Yoko Fukunaga
doaj   +1 more source

A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death

Frontiers in Immunology, 2018
Enhanced susceptibility to bacterial infection in the days following an acute virus infection such as flu is a major clinical problem. Mouse models have provided major advances in understanding viral-bacterial superinfections, yet interactions of the ...
Laurent Boucontet, Laurent Boucontet, Gabriella Passoni, Gabriella Passoni, Valéry Thiry, Valéry Thiry, Ludovico Maggi, Ludovico Maggi, Philippe Herbomel, Philippe Herbomel, Jean-Pierre Levraud, Jean-Pierre Levraud, Emma Colucci-Guyon, Emma Colucci-Guyon   +13 more
doaj   +1 more source

Macrophages promote the progression of premalignant mammary lesions to invasive cancer. [PDF]

, 2017
Breast cancer initiation, progression and metastasis rely on a complex interplay between tumor cells and their surrounding microenvironment. Infiltrating immune cells, including macrophages, promote mammary tumor progression and metastasis; however, less
Anderson, Bissell, Blair, Colombatti, Colombo, Condeelis, Coussens, De Palma, Earp, Ghosh, Green, Gunaratne, Hermoso, Hylton, Jensen, Jirstrom, Lewis, Lidereau, Luo, Lydon, Maatta, Machado, Mantovani, Naber, Naldini, Ochiai, Ochoa, Piemonti, Pollard, Pollard, Pollard, Pollard, Pollard, Porse, Rosen, Rosen, Rosen, Sarukhan, Schwertfeger, Schwertfeger, Shen, Strassmann, Suthipintawong, Ullrich, Van Ginderachter, Van Ginderachter, van Rooijen, Visvader, Wang, West   +49 more
core   +1 more source

Soluble ICAM‐1 a Pivotal Communicator between Tumors and Macrophages, Promotes Mesenchymal Shift of Glioblastoma

Advanced Science, 2022
Despite aggressive clinical treatment, recurrence of glioblastoma multiforme (GBM) is unavoidable, and the clinical outcome is still poor. A convincing explanation is the phenotypic transition of GBM cells upon aggressive treatment such as radiotherapy ...
Ki‐Chun Yoo, Jae‐Hyeok Kang, Mi‐Young Choi, Yongjoon Suh, Yi Zhao, Min‐Jung Kim, Jong Hee Chang, Jin‐Kyoung Shim, Seon‐Jin Yoon, Seok‐Gu Kang, Su‐Jae Lee   +10 more
doaj   +1 more source