Results 51 to 60 of about 1,368,417 (273)
Cellular Immunology, 2018 Obesity is a worldwide public health concern yet no safe therapies are currently available. The activity of sympathetic neurons is necessary and sufficient for fat mass reduction, via norepinephrine (NE) signaling. Macrophage accumulation in the adipose tissue is thought to play the central role in the onset of obesity, yet their relation to NE has ...
Ana Domingos +3 more
openaire +2 more sources
New Strategies to Promote Macrophage Cholesterol Efflux
Frontiers in Cardiovascular Medicine, 2021 The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi +3 more
doaj +1 more source
Journal of Extracellular Vesicles, 2021 Intravenous (IV) infusion of bone marrow‐derived mesenchymal stem/stromal cells (MSCs) stabilizes the blood‐spinal cord barrier (BSCB) and improves functional recovery in experimental models of spinal cord injury (SCI).
Masahito Nakazaki +4 more
doaj +1 more source
A lipid-structured mathematical model of atherosclerosis with macrophage proliferation [PDF]
arXiv, 2022 We extend the lipid-structured model for atherosclerotic plaque development of Ford et al. (2019) to account for macrophage proliferation. Proliferation is modelled as a non-local decrease in the lipid structural variable that is similar to the treatment of cell division in size-structured models (e.g. Efendiev et al. (2018)).
arxiv
Journal of Immunology, 1992 During normal tissue remodeling, macrophages remove unwanted cells, including those that have undergone programmed cell death, or apoptosis. This widespread process extends to the deletion of thymocytes (negative selection), in which cells expressing ...
V. Fadok +5 more
semanticscholar +1 more source
Macrophages and neurodegeneration
Brain Research Reviews, 2005 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Demyelination is a classical feature of MS lesions, and neurological deficits are often ascribed to the reduced signal conduction by demyelinated axons. However, recent studies emphasize that axonal loss is an important factor in MS pathogenesis
Hendriks, Jerome J A +3 more
openaire +4 more sources
Silk Particle Production Based on Silk/PVA Phase Separation Using a Microfabricated Co-flow Device
Molecules, 2020 Polymeric particles are ideal drug delivery systems due to their cellular uptake-relevant size. Microparticles could be developed for direct injection of drug formulations into a diseased site, such as a tumor, allowing for drug retention and slow drug ...
Natalia Vargas Montoya +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2017 Hereditary ATTR V30M amyloidosis is a lethal autosomal dominant sensorimotor and autonomic neuropathy caused by deposition of aberrant transthyretin (TTR).
Eleni Fella +11 more
doaj +1 more source
, 2014 Macrophages are part of the innate immune system, recognizing, engulfing, and destroying many potential pathogens including bacteria, pathogenic protozoa, fungi, and helminths. The destructive potential of macrophages and their ability to secrete regulators of the function of neighboring cells contribute to many aspects of homeostasis.
Sasmono, R.T., Hume, D. A.
openaire +3 more sources
Frontiers in Pharmacology, 2019 Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease.
Antonio Recchiuti +5 more
doaj +1 more source